Coronavirus Pandemic Short epidemiological overview of the current situation on COVID-19 pandemic in Southeast European (SEE) countries

We are living in times where a viral disease has brought normal life in much of the world to a halt. The novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) started in December 2019 in Wuhan, China initially and in a short time crossed the European borders. After mitigating the epidemic in China, Italy became one of the most COVID19 affected countries worldwide. International travelers are important sources of infectious diseases and a possible source of epidemic. Due to its political, geographic, and cultural similarities, Italy is one of the main economic partners of Southeast European (SEE) countries. Our data show that infection in index cases in all 11 SEE countries was travel-related with Italy being a source country for 8/11 countries. After the first case identifications on February 25, the number of cases in SEE countries is continually rising reaching the total number of 15,612 with 565 fatal cases and overall case fatality ratio (CFR) of 3.6 (median 3.8, range 0.8–5.5) by April 10, 2020. At a time when the COVID-19 pandemic is approaching its peak, apart from the problems with treatment of the disease and care for critically ill patients, there are other equally important problems, such as organization of outbreak response, provision of health care, lack of hospital personnel, disruption of personal protective equipment supply chains and health care workers (HCWs) protection. But what is more important is the heroic behavior of the HCWs who are showing their humanity by disregarding their lives.

COVID-19 can be characterized as a pandemic [5,6]. After outbreaks of the severe acute respiratory syndrome (SARS) in 2002/2003 and the Middle East respiratory syndrome (MERS) in 2012, COVID-19 is the third coronavirus epidemic in the third millennium underscoring the need for the ongoing surveillance of infectious disease trends throughout the world [2,6,7]. In most of the cases, the COVID-19 presents with mild to moderate respiratory illness without requiring special treatment. However, the elderly and people with comorbidities as hypertension, diabetes, cardiovascular and respiratory system diseases, and other underlying disease are more likely to develop serious illness requiring intensive care treatment associated with poorer clinical outcomes [8][9][10]. Even without strong evidences from randomized controlled trials confirming effective antiviral treatment against COVID-19, recent studies have revealed many attractive therapeutic options, such as antiviral agents remdesivir, favipiravir, lopinavir/ritonavir, chloroquine, arbidol, and ribavirin. Several other treatment options, e.g., antiparasitic drugs (hydroxychloroquine), investigational antivirals (camostat mesylate), immunotherapeutic (tocilizumab), and convalescent plasma are under investigation in clinical trials or are being considered for clinical use [1,6,[11][12][13][14].
On the other hand, international travelers are important sources of infectious diseases and a possible source of epidemic [15][16][17]. Most of the internationally exported cases at the beginning of the pandemic originated from China. Two weeks after the first report of the COVID-19 cases in China, travel-related cases have been reported from Thailand, Japan, and South Korea followed by other neighbouring Southeast Asian countries, all related to travels from China [4,15,17,18]. However, among Southeast European (SEE) countries there were no imported cases from China.
After mitigating the epidemic in China, on Febraury Italy became one of the most COVID-19 affected countries worldwide, where the number of cases are still dramatically raising [19,20]. Hence, the infection spreads by immigration, traveling, or seasonal employment in endemic areas [17]. In these conditions, when a large number of people travels each year to developing countries as tourism destinations, an obvious part of the confirmed COVID-19 cases originate from these areas [16]. Due to its political, geographic, and cultural similarities, Italy is one of the main economic partners in terms of foreign trade and investments, of SEE countries, especially Slovenia, Croatia, Montenegro and Albania. In addition, bilateral and multilateral agreements have increased cooperation in the fields of science, education, labor and tourism. All this has led to an increased transfer of people and goods, especially tourists and migrant workers, between Italy and the neighboring SEE countries (The Italian Ministry of Foreign Affairs and International Cooperation. Italy -Balkans Bilateral Relations. https://www.esteri.it/mae/en/politica_estera/aree_geog rafiche/europa/balcani). Thousands of citizens from SEE countries are residents, immigrants or seasonal workers in Italy and many of them fly or drive back and forth regularly for work and personal travel. Since Italy is one of the most important trade and travel connection with Southeast Europe, the aim of this paper was to determine the effect of the migration between Italy and SEE countries on the spread of the epidemic to these countries.
Imported cases of COVID-19 have arrived in SEE countries quickly after the beginning of the outbreak in the regions of Lombardy and Veneto in northern Italy. As shown in Table 1, the first case in SEE countries was identified in Croatia on February 25, followed by Greece, North Macedonia, Romania, Slovenia, Bosnia and Herzegovina, Serbia, Bulgaria, Albania, Kosovo, and Montenegro. Moreover, in some countries such as Croatia, Slovenia, Bosnia and Herzegovina, Albania and North Macedonia, a few clusters of COVID-19 imported from Italy were registered that makes epidemiological monitoring much more difficult. Since the first identification on February 25, the number of cases has been rising constantly reaching the total number of 15,612 with 565 fatal cases and overall case fatality ratio (CFR) of 3.6 (median 3.8, range 0. 8-5.5). Based on the case definition [21] and incubation of up to 14 days, travel history and contact tracing, infection in index cases in all 11 SEE countries was travel-related with Italy being as a source country for 8/11 countries (Table 1) [22].
The world has faced a lot of epidemics since ancient times. The epidemic usually occurs when the health care system is not well prepared. During an unexpected epidemic, health authorities are well engaged in outbreak response and damage control only if recognising and understanding the possible threat. Nothwithstanding recent outbreaks show how difficult this could it be, even with good health care systems. However, initially delay in recognising and the lack of knowledge on transmission, prevention, and treatment of the infectious disease may contribute to widespread of the epidemic/outbreak [23]. Europe and SEE countries faced these shortcomings, too. But the question is: Are healthcare systems in the SEE countries sufficiently prepared to face such a huge epidemic? A large heterogeneity exists in the demographic, social, economic, and political dimensions in SEE countries [24]. Some of the countries are part of European community and some other are trying to be a part of it.
Even more, the medical systems in these countries have been hit hardly by the massive emigration of doctors and nurses over the past few years. Migration of medical staff has become a global phenomenon with significant implications for the healthcare delivery systems worldwide [25]. The massive growth in the migration of medical doctors, nurses and other healthcare workers (HCWs) from SEE countries, mainly to European Union, seems to be one of the major obstacles in COVID-19 pandemic preparedness in developing countries. This phenomenon has a significant impact on the quality of healthcare systems in the source countries generally. The healthcare systems in this region are fragile. From the government, all medical staff, including retired, private doctors or hospitals, medical graduate students are required to volunteer in this situation. Looking at this point, we hope to have a limited number of serious cases in order not to overload the health system [26,27]. The burden that will press on the region would be an additional challenge to the healthcare systems and economies. Multiple social and economic issues are ongoing and will impact the situation, including the massive refugees' migration from Syria to Turkey and Greece [28,29]. Nevertheless, the SEE countries have considerably fewer coronavirus cases compared with the other parts of Europe. They are trying to step up their preparedness to cope with COVID-19 outbreak. The countries in this region, and especially Albania, have taken a range of restrictive steps, from cutting off travel links to closing down schools, universities, bars, restaurants, manufactures and are placed under strict quarantine measures.
Another huge concern is the high rate of SARS-CoV-2 exposure and infection among HCWs during the COVID-19 pandemic. HCWs constituted a large proportion of the cases, ranging from 3.8 to 29% [2,30,312]. Additionally, due to both occupational and non-occupational exposure to SARS-CoV-2, many HCWs are obliged to quarantine resulting in excluding many HCWs from working facilities for 14 days [32][33][34]. At a time when the COVID-19 pandemic is approaching its peak, apart from the problem of not known specific treatment of the disease and care for critically ill patients, there is another equally important problem -procurement of personal protective equipment (PPE) for HCWs. The PPE is absolutely necessary to protect HCWs, as well as patients themselves [7,23,24,[33][34][35][36][37]. However, the exact profile will be more obvious by the end of the pandemic since numbers of cases are still increasing. The direct contact with COVID-19 infected patients, along with the lack of compliance to PPE, HCWs are at the highest risk of acquiring infection. The PPE is absolutely necessary to protect exposed staff, as well as patients themselves [35]. It is currently the most sought after commodity on the world market and it is evident that its production does not meet the real need for it. Countries where there are protective equipment factories generally keep most of the manufactured material within their borders for the needs of their healthcare facilities. On the other hand, countries like Bosnia and Herzegovina or most other Balkan countries do not possess that kind of production facilities leading to many difficulties in purchasing, importing and distributing PPE to hospitals, and greatly affecting the quality of medical service as these institutions are forced to economize its usage. The fact that China is gradually emerging from this epidemic and rebuilding its economy, gives hope that its huge share in world production will overcome this problem in the near future. What is more important is the heroic behavior of the HCWs, who are showing their humanity by disregarding their lives. More than 30 medical staff are joint their colleagues in Italy to support them in this battle again COVID-19. So let it serve as a lesson to discuss the organizing and evaluating of every disease in the health care system over the next few years. Special regards to all who struggled in this epidemic situation for our future! Especially to HCWs and inhabitants of Croatian capital of Zagreb since the city of Zagreb was struck by a major earthquake amidst the COVID-19 epidemic, while the spread of the epidemic has not accelerated and the country still has one of the lowest COVID-19 rates in Europe. We have learned that we cannot do without one another: physicians without nurses, patients without HCWs, HCWs without non-medical staff, parents without children, and children without parents [38].
One of the limitations of our paper is none included of Turkey, because it has a lot of differences with other southeastern countries.

Conclusion
The COVID-19 pandemic is one of the most serios problem in now days. The world will learn from this pandemic in sense of: medical system organization; protection of medical staff and the general population; supporting of which others; economics and collaborations.