Efficacy and safety of linezolid versus teicoplanin for the treatment of MRSA infections: a meta-analysis

  • Hao Chen School of Pharmacy, Anhui Medical University, Hefei, Anhui, China
  • Lan Li School of Pharmacy, Anhui Medical University, Hefei, Anhui, China
  • Maomao Wu School of Pharmacy, Anhui Medical University, Hefei, Anhui, China
  • Shuangli Xu School of Pharmacy, Anhui Medical University, Hefei, Anhui, China
  • Mingli Wang Anhui Medical University, Hefei, Anhui, China
  • Jiabin Li Anhui Medical University, Hefei, Anhui, China
  • Xiaohui Huang School of Pharmacy, Anhui Medical University, Hefei, Anhui, China
Keywords: linezolid, teicoplanin, methicillin-resistant Staphylococcus aureus, MRSA, meta-analysis

Abstract

Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of serious infections. Linezolid and teicoplanin are widely used in the treatment of infections caused by MRSA. However, the efficacy and safety of linezolid compared with teicoplanin remains controversial. The purpose of this study was to systematically review the efficacy and safety of linezolid versus teicoplanin for the treatment of MRSA infections.

Methodology: A meta-analysis was performed on the published studies. Pooled relative risk (RR) and 95% confidence interval (95% CI) were calculated to determine whether there were significant differences between the linezolid group and the teicoplanin group on the efficacy and safety.

Results: Seventeen studies were included, involving 2,040 patients. The results showed that linezolid was associated with better clinical cure rate (RR = 1.14, 95% CI = 1.08-1.21, p < 0.00001) and microbiological eradication rate (RR = 1.28, 95% CI = 1.18-1.39, p < 0.00001) compared with teicoplanin. There were no statistically significant differences between the two groups in the treatment of MRSA infections regarding the adverse events (RR = 1.15, 95% CI = 0.97-1.35, p = 0.10) and the mortality (RR = 0.85, 95% CI = 0.61-1.18, p = 0.33).

Conclusions: The results suggest that linezolid may be a better choice for the treatment of patients with MRSA infections. However, our recommendation is that the decision about treating MRSA infections with linezolid or with teicoplanin should depend on local availability, patient population, dosage regimens, costs and safety, rather than presumed differences in efficacy.

Published
2018-01-10
How to Cite
1.
Chen H, Li L, Wu M, Xu S, Wang M, Li J, Huang X (2018) Efficacy and safety of linezolid versus teicoplanin for the treatment of MRSA infections: a meta-analysis. J Infect Dev Ctries 11:926-934. doi: https://doi.org/10.3855/jidc.9447
Section
Original Articles