Bacterial profile and antibiogram of blood stream infections in febrile neutropenic patients with haematological malignancies

  • Prathyusha Kokkayil Government Medical College, Palakkad, Kerala, India
  • Reshu Agarwal All India Institute of Medical Sciences, New Delhi, India
  • Sarita Mohapatra All India Institute of Medical Sciences, New Delhi, India
  • Sameer Bakshi All India Institute of Medical Sciences, New Delhi, India
  • Bimal Das All India Institute of Medical Sciences, New Delhi, India
  • Seema Sood All India Institute of Medical Sciences, New Delhi, India
  • Benu Dhawan All India Institute of Medical Sciences, New Delhi, India
  • Arti Kapil All India Institute of Medical Sciences, New Delhi, India
Keywords: bloodstream infection, Klebsiella pneumoniae, antibiotic resistance, febrile neutropenia, haematological malignancy

Abstract

Introduction: Studies have shown a shift in the prevalence from Gram-positive to Gram-negative bacteraemia in patients with haematological malignancies who develop febrile neutropenia. There are also reports on the spread of drug resistant bacteria among these patients. Information about locally prevalent bacteria and their resistance is important to guide empirical therapy. The aim of this study was to characterise the bacterial spectrum and antibiotic resistance pattern of bacteraemia in neutropenic patients with haematological malignancies

Methodology: In this retrospective study, patients admitted to Haematology and Oncology units over a period of 6 months with laboratory-confirmed positive blood cultures were enrolled. Information regarding demographic profile, clinical features, and microbiological profile were recorded. Standard procedures were applied to identify the isolates and their resistance patterns. The data collected was analysed statistically.

Results:56 isolates from 53 patients were isolated of which majority were gram negative bacilli (GNB; n = 52 or 93%). Klebsiella pneumoniae (43%, n = 24) was the most frequently isolated bacteria followed by Enterobacter sp (20%, n = 11) and Escherichia coli (12%, n = 7). All isolates were susceptible to colistin. Susceptibility to cefaperazone-sulbactam, piperacillin-tazobactam and carbapenems were 32%, 28.6% and 26.8% respectively. The outcome was fatal for 25 patients.

Conclusions: The study documented an alarming rise in the prevalence of GNB and their resistance. Though the results of the study may represent only the tip of the iceberg, the results demonstrate the need for treatment options for drug resistant isolates and for surveillance cultures.

Author Biographies

Prathyusha Kokkayil, Government Medical College, Palakkad, Kerala, India

Department of Microbiology

Reshu Agarwal, All India Institute of Medical Sciences, New Delhi, India

Department of Microbiology

Sarita Mohapatra, All India Institute of Medical Sciences, New Delhi, India

Department of Microbiology

Sameer Bakshi, All India Institute of Medical Sciences, New Delhi, India

Department of Medical Oncology, Dr. B.R.A. Institute Rotary Cancer Hospital

Bimal Das, All India Institute of Medical Sciences, New Delhi, India

Department of Microbiology

Seema Sood, All India Institute of Medical Sciences, New Delhi, India

Department of Microbiology

Benu Dhawan, All India Institute of Medical Sciences, New Delhi, India

Department of Microbiology

Arti Kapil, All India Institute of Medical Sciences, New Delhi, India

Department of Microbiology

Published
2018-06-30
How to Cite
1.
Kokkayil P, Agarwal R, Mohapatra S, Bakshi S, Das B, Sood S, Dhawan B, Kapil A (2018) Bacterial profile and antibiogram of blood stream infections in febrile neutropenic patients with haematological malignancies. J Infect Dev Ctries 12:442-447. doi: https://doi.org/10.3855/jidc.9725
Section
Original Articles

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