@article{Zhao_Yan_Shi_Zhang_Ming_2017, title={In silico identification of cytotoxic T lymphocyte epitopes encoded by RD5 region of Mycobacterium tuberculosis}, volume={11}, url={https://jidc.org/index.php/journal/article/view/31600154}, DOI={10.3855/jidc.7207}, abstractNote={<p>Introduction: While CD8+ T cells (cytotoxic T lymphocytes, CTLs) play important roles in immunity against<em> Mycobacterium tuberculosis</em>, only a small number of human leukocyte differentiation antigen (HLA) class I-restricted CTL epitopes for TB have been identified. The current study evaluates CTL epitopes of Rv3117 and Rv3120 proteins, two newly found <em>M. tuberculosis</em> region-diffference-5 (RD5)-encoded antigens, and their population coverage.</p> <p>Methodology: The amino acid sequences of the two proteins were subjected to epitope analysis under HLA-A2, A3 and B7 supertype restriction using NetCTL, SYFPEITHI, BIMAS, NetCTLPan, IEDB, NetMHC and NetMHCPan prediction online servers.</p> <p>Results: Eight RD5-encoded CTL epitopes were identified in the two proteins and the average population coverage of these epitopes was 87.2% among populations worldwide.</p> <p>Conclusion: These CTL epitopes that were identified <em>in</em> <em>silico</em> and may have potential use for CD8+ T cell-mediated TB vaccine design.</p>}, number={10}, journal={The Journal of Infection in Developing Countries}, author={Zhao, Jun-Wei and Yan, Min and Shi, Guang and Zhang, Shu-Lin and Ming, Liang}, year={2017}, month={Oct.}, pages={806–810} }