@article{Liu_Liu_Li_Hao_2017, title={Association between virulence profile and fluoroquinolone resistance in Escherichia coli isolated from dogs and cats in China}, volume={11}, url={https://jidc.org/index.php/journal/article/view/28459221}, DOI={10.3855/jidc.8583}, abstractNote={<p class="SmallText">Introduction: <em>Escherichia coli</em> is not only a commensal organism in humans and animals, but also a causative agent of diarrhea and extraintestinal infections. Information about the relationship between population structure, virulence gene profiles, and fluoroquinolone resistance of <em>E. coli </em>in dogs and cats in China is limited.</p> <p class="SmallText">Methodology: A total of 174 pathogenic and commensal <em>E. coli</em> isolates were evaluated in terms of phylogenetic group, virulence gene profile, sequence types (STs), and fluoroquinolone susceptibility.</p> <p class="SmallText">Results: A total of 46.6% of isolates belonged to phylogenetic group B2. Isolates displayed high resistance to tetracycline (82.2%), amoxicillin/clavulanic acid (73.6%), gentamicin (62.1%), and enrofloxacin (60.9%). <em>fimH</em> (81.6%) was the most prevalent virulence gene, and 83.9% of isolates contained one or more investigated virulence genes. The majority of the investigated virulence genes were more prevalent in fluoroquinolone-susceptible isolates and pathogenic isolates. Multilocus sequence typing (MLST) showed that <em>E. coli</em> isolates analyzed were assigned to 65 STs. Among of them, pathogenic-resistant and pathogenic-susceptible isolates had 44 and 10 STs, respectively, while there were 8 and 3 STs in the commensal resistant and susceptible isolates, respectively.</p> <p class="SmallText">Conclusions: Phylogenetic group B2 was the dominant group, accounting for 46.6% of the isolates. Pathogenic isolates and fluoroquinolone-susceptible isolates possessed more virulence genes. Pathogenic isolates and fluoroquinolone-resistant isolates exhibited high population diversity, and pandemic clone ST131 appeared in 9.8% of isolates.</p>}, number={04}, journal={The Journal of Infection in Developing Countries}, author={Liu, Xiaoqiang and Liu, Haixia and Li, Yinqian and Hao, Caiju}, year={2017}, month={Apr.}, pages={306–313} }