@article{Liu_Wang_Lin_Cai_Cui_Wu_2018, title={Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study}, volume={12}, url={https://jidc.org/index.php/journal/article/view/31865299}, DOI={10.3855/jidc.9845}, abstractNote={<p>Introduction: In clinical perspectives, how to distinguish a small proportion of children at risk of developing neurological complications from a large number of children with mild symptoms still remains a challenge for primary care doctors.</p> <p>Methodology: From January 2012 to December 2015, 225 cases with severe hand, foot and mouth disease (HFMD) matched with 492 controls were enrolled in the age-matched, case-control study. Continuous variables were examined by univariate analysis using a chi-squared or Fisher’s exact test, and categorical variables were reported by relative risks (odd’s ratio). Multivariate logistic regression was used to analyze the independent risk factors for severe HFMD.</p> <p>Results: Peak body temperature over 37.5℃,total duration of fever over 3 days, lethargy, enterovirus 71 (EV71) infection were independent risk factors for severe HFMD.</p> <p>Conclusions: Peak body temperature over 37.5℃,total duration of fever over 3 days, lethargy, EV71 infection were independent risk factors for severe HFMD.</p>}, number={05}, journal={The Journal of Infection in Developing Countries}, author={Liu, Chunhua and Wang, Kaiyan and Lin, Niyang and Cai, Jianling and Cui, Binglin and Wu, Beiyan}, year={2018}, month={May}, pages={359–364} }