TY - JOUR AU - Zhang, Di AU - Cui, Kai AU - Wang, Taotao AU - Shan, Yuanyuan AU - Dong, Haiyan AU - Feng, Weiyi AU - Ma, Chen AU - Dong, Yalin PY - 2018/08/31 Y2 - 2024/03/29 TI - Risk factors for carbapenem-resistant Pseudomonas aeruginosa infection or colonization in a Chinese teaching hospital JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 12 IS - 08 SE - Original Articles DO - 10.3855/jidc.10150 UR - https://jidc.org/index.php/journal/article/view/31958327 SP - 642-648 AB - <p>Introduction: Carbapenem-resistant <em>Pseudomonas aeruginosa</em> (CRPA) is rapidly emerging as a life-threatening nosocomial infection. In this study, we aimed to identify risk factors, especially antibiotic use and co-carriage with other bacteria for CRPA infection or colonization.</p><p>Methodology: A retrospective study was conducted in the First Affiliated Hospital of Xi’an Jiaotong University, which involved a cohort of patients with <em>Pseudomonas aeruginosa</em> infection or colonization from January 2014 to June 2016. Univariate analysis and multivariate analysis were performed to estimate the risk factors of CRPA occurrence.</p><p>Results: Eight hundred and eighty-eight patients were included in the study. More than 50% of the risk factors were associated with CRPA infection or colonization according to univariate analysis (<em>P</em> &lt; 0.05), such as invasive procedures, co-carriage with Gram-negative pathogens, and prior treatment with some antibiotics. However, only prior exposure to carbapenems (OR: 8.005; CI:4.507-14.217, <em>P</em>&lt;0.001), the days of carbapenems treatment (OR: 1.190; CI: 1.073-1.272; <em>P</em> &lt; 0.001), and co-carriage with <em>Escherichia coli </em>(OR: 1.824; CI: 1.005-3.310, <em>P</em> = 0.048) were considered independent risk factors by multivariate analysis. A higher mortality was found among patients with CRPA infection or colonization (<em>P</em> &lt; 0.05).</p><p>Conclusions: Risk factors for CRPA infection or colonization were prior exposure to carbapenems, the days of carbapenems treatment, and co-carriage with <em>Escherichia coli</em>. The prevalence of CRPA could be influenced by Gram-negative pathogens, especially in <em>Escherichia coli</em>, and it need more researches. Moreover, restrictions in the clinical use of carbapenems should be taken into account.</p> ER -