TY - JOUR AU - Lukic, Ruzica AU - Cupic, Maja AU - Gajovic, Nevena AU - Jurisevic, Milena AU - Mijailovic, Zeljko AU - Davidovic, Bojana AU - Kujundzic, Bojan AU - Joksimovic, Bojan AU - Arsenijevic, Nebojsa AU - Jovanovic, Ivan PY - 2020/05/31 Y2 - 2024/03/28 TI - Increased systemic sST2 in patients with end stage renal disease contributes to milder liver damage during HCV infection JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 14 IS - 05 SE - Original Articles DO - 10.3855/jidc.11741 UR - https://jidc.org/index.php/journal/article/view/32525839 SP - 519-526 AB - <p>Introduction: Hepatitis C Virus (HCV) is the leading cause of chronic liver disease and is a serious global health problem. Hepatitis C infection is highly prevalent in patients with end stage renal disease (ESRD), due to frequent exposure to blood and blood products, nosocomial transmission of HCV, and prolong hemodialysis duration. The aim of the study was to evaluate the influence of IL-33/ST2 signaling pathway on severity of the liver disease in ESRD HCV<sup>+</sup> patients.</p><p>Methodology: Blood samples from patients with end stage renal disease (ESRD) and hepatitis C infection (HCV), 20 patients with HCV infection, 20 patients with ESRD and 20 healthy control donor patients were taken for the examination of biochemical parameters, for the determination of the serum cytokine concentration, and for the molecular diagnostics of HCV.</p><p>Results: Systemic sST2 positively correlated with serum level of urea and creatinine, respectively. Serum sST2 was significantly increased in ESRD HCV+ patients in comparison to HCV+ group. sST2/IL-1, sST2/IL-4 and sST2/IL-23 ratios were significantly increased in serum of ESRD HCV+ patients in comparison to HCV+ patients. Significantly higher systemic level of sST2 and sST2/IL-1 and sST2/IL-4 ratios were measured in ESRD patients compared to non-ESRD patients.</p><p>Conclusion: These results suggested that elevated level sST2, as the consequence of renal failure, causes less destruction of liver in HCV infection.</p> ER -