TY - JOUR AU - Uskudar Guclu, Aylin AU - Altay Kocak, Aylin AU - Akcil Ok, Mehtap AU - Tutluoglu, Bulent AU - Basustaoglu, Ahmet Celal AU - Respiratory Study Group, PY - 2021/03/07 Y2 - 2024/03/29 TI - Antibacterial Resistance in Lower Respiratory Tract Bacterial Pathogens: A Multicenter Analysis from Turkey JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 15 IS - 02 SE - Original Articles DO - 10.3855/jidc.12599 UR - https://jidc.org/index.php/journal/article/view/33690209 SP - 254-262 AB - <p>Introduction: This study aimed to evaluate the etiology of lower respiratory tract infections (LRTIs) and their antibiotic resistance.</p><p>Methodology: Bacterial culture results of LRT samples from 17 hospitals between 2016-2019 were included in the study. All isolates were identified and AST were performed by automated microbiology systems. AST was performed according to EUCAST.</p><p>Results: Non-duplicate 30,051 (26,890 HA and 3156 CA) isolates detected as causative pathogen. LRTIs are caused by 85.1% Gram-negative bacterial pathogens and 14.9% Gram-positive. The most common isolates among HA pathogens were <em>Acinetobacter spp</em>. (27.4%), <em>P.aeruginosa</em> (22.2%), <em>K.pneumoniae</em> (17.9%); among CA pathogen <em>S.pneumoniae</em> (19.9%), <em>P. aeruginosa</em> (18.9%), <em>H.influenzae</em> (14.6%). ESBL rate was 62.5% in <em>K.penumoniae</em>; 53.1% in <em>E.coli</em>; 19.1% in <em>Klebsiella spp</em>; 13.9% in <em>Enterobacter spp</em>.; 8.6% in <em>Proteus spp</em>.; 6.3% in <em>Citrobacter spp</em>.; and 4.3% in <em>Serratia spp</em>. Resistance rates to carbapenems and colistin were 92.8% and 12.8% in <em>A baumannii</em>, 39.8% and 7.5% in <em>P.aeruginosa</em>, 47.3% and 18.5% in <em>K.penumoniae</em>. Among staphylococci, 27.3% of <em>S. aureus</em> and 82.4% of CoNS were methicillin resistant. 7.6% of <em>E.faecium</em> and 0.9% of <em>E.faecalis</em> were vancomycin resistant.&nbsp; Linezolid resistant <em>S. aureus</em>, CoNS, <em>E.faecalis</em> and <em>E.faecium</em> rates were 0.3%, 2.9%, 0.0% and 4.6%. Inducible clindamycin resistant rate was 17.2% in <em>S. aureus</em> 38.2% in CoNS. Non-susceptible <em>S.pneumoniae</em> isolate rate to penicillin was 37.0%. 6.5% of <em>S.maltophilia</em> and 4.4% of <em>B.cepacia</em> isolates were resistant to trimethoprim/sulfamethoxazole.</p><p>Conclusions: Antibiotic resistance was mainly observed among <em>A.baumannii</em> and <em>K.pneumoniae</em> and continuous surveillance of antimicrobial resistance patterns in the management of LRTIs is important.</p><p>&nbsp;</p> ER -