TY - JOUR AU - Zhang, Tianchen AU - Ding, Sheng AU - Zeng, Zhili AU - Cheng, Huijian AU - Zhang, Chengfeng AU - Mao , Xiangqun AU - Pan , Huanhong AU - Xia, Guanghui AU - Che, Daping PY - 2021/03/31 Y2 - 2024/03/28 TI - Estimation of Incubation Period and Serial Interval for SARS-CoV-2 in Jiangxi, China, and an Updated Meta-Analysis JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 15 IS - 03 SE - Coronavirus Pandemic DO - 10.3855/jidc.14025 UR - https://jidc.org/index.php/journal/article/view/33839705 SP - 326-332 AB - <p>Introduction: This paper aims to estimate the incubation period and serial intervals for SARS-CoV-2 based on confirmed cases in Jiangxi Province of China and meta-analysis method.</p><p>Methodology: Distributions of incubation period and serial interval of Jiangxi epidemic data were fitted by “fitdistrplus” package of R software, and the meta-analysis was conducted by “meta” package of R software.</p><p>Results: Based on the epidemic data of Jiangxi, we found the median days of incubation period and serial interval were 5.9 days [IQR: 3.8 – 8.6] and 5.7 days [IQR: 3.6 – 8.3], respectively. The median days of the infectivity period at pre-symptomatic was 1.7 days [IQR: 1.1 – 2.4]. The meta-analysis based on 64 papers showed the pooled means of the incubation period and serial interval were 6.25 days (95% CrI: 5.75 – 6.75) and 5.15 days (95% CrI: 4.73 – 5.57), respectively.</p><p>Conclusions: Our results contribute to a better understanding of COVID-19 and provide useful parameters for modelling the dynamics of disease transmission. The serial interval is shorter than the incubation period, which indicates that the patients are infectious at pre-symptomatic period, and isolation of detected cases alone is likely to be difficult to halt the spread of SARS-CoV-2.</p> ER -