TY - JOUR AU - Adnan, Muhammad AU - Hashmat, Naheed AU - Rahat, Tayyaba AU - Burki, Ayousha PY - 2022/01/31 Y2 - 2024/03/29 TI - Prognostic value of five serum markers predicting in–hospital mortality among adults with community acquired pneumonia JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 16 IS - 01 SE - Original Articles DO - 10.3855/jidc.14495 UR - https://jidc.org/index.php/journal/article/view/35192534 SP - 166-172 AB - <p>Introduction: To evaluate the prognostic value of serum markers predicting in–hospital mortality among community acquired pneumonia patients</p><p>Methodology: Total 134 patients admitted in Sir Ganga Ram Hospital Lahore Pakistan during 2014–16 included. Serum markers recorded upon admission included blood urea nitrogen, albumin, creatinine, blood urea nitrogen/albumin ratio and blood urea nitrogen/creatinine ratio. Patients were observed for the incidence of mortality during hospitalization. Comparison between survivors and non–survivors for means by t test; odds ratios by contingency tables; and effectiveness of predictors by receiver operating characteristic curve analyses were assessed.</p><p>Results: Overall mean age was 50 ± 21 years; males 45.5%; and in–hospital mortality 9.7%. For in–hospital mortality, creatinine ≥ 2.8 mg/dL showed the highest odds (OR = 7.656, 95% CI = 2.281–25.692; <em>p</em> = 0.001); followed by CURB-65 score ≥ 4 (OR = 4.958, 95% CI = 0.418–58.784; <em>p</em> = 0.266); and blood urea nitrogen ≥ 24.7 mg/dL (OR = 3.364, 95% CI = 1.033–10.954; <em>p</em> = 0.062). Serum creatinine was a fair predictor of in–hospital mortality (AUC = 0.721) showed 53.0% sensitivity and 87.0% specificity at cut–off 2.8 mg/dL. Blood urea nitrogen (AUC = 0.691) and blood urea nitrogen/albumin ratio (AUC = 0.675) were poor predictors; whereas albumin (AUC = 0.424) and blood urea nitrogen/creatinine ratio (AUC = 0.403) failed to predict in–hospital mortality.</p><p>Conclusions: Among five serum markers, raised serum creatinine was a better predictor of in–hospital mortality in adults with community acquired pneumonia.</p> ER -