TY - JOUR AU - Saglik, Imran AU - Ener, Beyza AU - Akalin, Halis AU - Ozdemir, Buşra AU - Ocakoglu, Gokhan AU - Yalcin, Baris AU - Onal, Ugur AU - Aydin Guçlu, Ozge AU - Acet Ozturk, Nilufer Aylin AU - Tuzemen, Ulku AU - Demirdogen, Ezgi AU - Gorek Dilektasli, Asli AU - Agca, Harun AU - Kazak, Esra AU - Coskun, Funda AU - Heper, Yasemin AU - Payaslioglu, Melda AU - Ediger, Dane AU - Ursavas, Ahmet AU - Yilmaz, Emel AU - Ozakin, Cuneyt AU - Uzaslan, Esra AU - Karadag, Mehmet PY - 2022/03/31 Y2 - 2024/03/29 TI - Association of SARS-CoV-2 cycle threshold (Ct) values with clinical course and serum biomarkers in COVID-19 patients JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 16 IS - 03 SE - Coronavirus Pandemic DO - 10.3855/jidc.15818 UR - https://jidc.org/index.php/journal/article/view/35404849 SP - 445-452 AB - <p>Introduction: Our knowledge has gaps regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication levels and its association to severity of Coronavirus disease 2019 (COVID-19). The aim of this study was to investigate the association of SARS-CoV-2 viral load with disease severity and serum biomarkers in COVID-19 patients.</p><p>Methodology: Viral load was determined via cycle threshold (Ct) values of SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 214 adult patients. Ct values were compared with clinical severity, biochemical and hematological biomarkers.</p><p>Results: Clinical course of the disease was mild (49.1%), moderate (40.2%), and severe (10.7%). Median Ct value was 28.2 (IQR: 22.2–33.8) during the first week of the disease. Ct values were lower within five days after symptom onset [lowest Ct value on the third day (median: 24, IQR: 20.6–32.3)], but they increased significantly during the second and third weeks. No association was detected between admission Ct values and disease severity. Gender, age, co-morbidity, and mortality did not differ significantly in patients with low (≤ 25) and high (&gt; 25) Ct values. White blood cell, neutrophil, platelet, and especially lymphocyte counts, were significantly lower in patients with low Ct values.</p><p>Conclusions: No definitive/clear correlation between SARS-CoV-2 viral load and severity and mortality was found in the studied COVID-19 patients. However, neutrophil, platelet, and especially lymphocyte count were significantly lower in patients with a high viral load.</p> ER -