TY - JOUR AU - Liu, Linlin AU - Guo, Lingyun AU - Wang, Zhuangzhuang AU - Wang, Qiang AU - Zeng, Jinjin AU - Chen, Tianming AU - Liu, Gang PY - 2023/04/30 Y2 - 2024/03/29 TI - Pediatric deep venous thrombosis associated with Staphylococcus aureus osteomyelitis JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 17 IS - 04 SE - Original Articles DO - 10.3855/jidc.17026 UR - https://jidc.org/index.php/journal/article/view/37159886 SP - 494-499 AB - <p class="SmallText" style="text-align: justify; text-justify: inter-ideograph;"><span lang="EN-US">Introduction: Our objective was to evaluate clinical features of children with deep venous thrombosis (DVT) and acute hematogenous osteomyelitis (AHO) caused by <em>Staphylococcus aureus</em>.</span></p><p class="SmallText" style="text-align: justify; text-justify: inter-ideograph;"><span lang="EN-US">Methodology: We analyzed 4 years of medical records of patients with AHO and DVT caused by <em>Staphylococcus aureus</em> (<em>S. aureus</em>) and compared clinical and biochemical characteristics of AHO with and without DVT, as well as patients whose DVT dissolved in ≥ 3 weeks. </span></p><p class="SmallText" style="text-align: justify; text-justify: inter-ideograph;"><span lang="EN-US">Results: DVT was found in 19/87 AHO individuals (22%). The median age was 9 years (range: 0.5-15 years). 74% (14/19) patients were boys. Methicillin-susceptible <em>Staphylococcus aureus</em> (MSSA) was present in 58% (11/19) cases. The femoral vein and common femoral vein were the two most damaged veins (9 cases each). Anticoagulation therapy with low molecular weight heparin was given to 18 (95%) patients. Within 3 weeks of anticoagulation, 7/13 (54%) with available data had completely resolved DVT. There was no rehospitalization due to bleeding or recurrent DVT. Patients with DVT were found to be older and had increased levels of C-reactive protein, procalcitonin, D-dimer, positive blood culture, incidence of intensive care unit admission, multifocal rate, and length of hospital stay. We did not find clinical difference between patients whose DVT dissolved within 3 weeks and those with &gt; 3 weeks.</span></p><p class="SmallText" style="text-align: justify; text-justify: inter-ideograph;"><span lang="EN-US">Conclusions: Over 20% of patients with <em>S. aureus</em> AHO developed DVT. MSSA accounted for more than half of the cases. DVT was completely resolved in more than half of the cases after 3 weeks of anticoagulant medication, with no sequelae.</span></p> ER -