TY - JOUR AU - Turhan, Vedat AU - Mutluoglu, Mesut AU - Acar, Ali AU - Hatipoglu, Mustafa AU - Onem, Yalcın AU - Uzun, Gunalp AU - Ay, Hakan AU - Oncul, Oral AU - Gorenek, Levent PY - 2013/10/15 Y2 - 2024/03/29 TI - Increasing incidence of Gram-negative organisms in bacterial agents isolated from diabetic foot ulcers JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 7 IS - 10 SE - Original Articles DO - 10.3855/jidc.2967 UR - https://jidc.org/index.php/journal/article/view/24129622 SP - 707-712 AB - <p class="SmallText">Introduction: In the present study, we sought to identify the bacterial organisms associated with diabetic foot infections (DFIs) and their antibiotic sensitivity profiles.</p> <p class="SmallText">Methodology: We retrospectively reviewed the records of wound cultures collected from diabetic patients with foot infections between May 2005 and July 2010.</p> <p class="SmallText">Results: We identified a total of 298 culture specimens (165 [55%] wound swab, 108 [36%] tissue samples, and 25 [9%] bone samples) from 107 patients (74 [69%] males and 33 [31%] females, mean age 62 ± 13 yr) with a DFI. Among all cultures 83.5% (223/267) were monomicrobial and 16.4% (44/267) were polymicrobial. Gram-negative bacterial isolates (n = 191; 61.3%) significantly outnumbered Gram-positive isolates (n = 121; 38.7%). The most frequently isolated bacteria were <em>Pseudomonas</em> species (29.8%), <em>Staphylococcus aureus</em> (16.7%), <em>Enterococcus</em> species (11.5%), <em>Escherichia coli</em> (7.1%), and <em>Enterobacter</em> species (7.1%), respectively. While 13.2% of the Gram-negative isolates were inducible beta-lactamase positive, 44.2% of <em>Staphylococcus aureus</em> isolates were methicillin resistant.</p> <p class="SmallText">Conclusions: Our results support the recent view that Gram-negative organisms, depending on the geographical location, may predominate in DFIs.</p> ER -