TY - JOUR AU - Wang, Wen AU - Li, Wei AU - Yang, Xue AU - Zhang, Tong AU - Wang, Yuxuan AU - Zhong, Rui AU - Jiao, Yanmei AU - Li, Tongzeng AU - Jiang, Taiyi AU - Tian, Yakun AU - Wu, Hao PY - 2014/01/15 Y2 - 2024/03/29 TI - Interleukin-8 is elevated in severe hand, foot, and mouth disease JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 8 IS - 01 SE - Original Articles DO - 10.3855/jidc.3542 UR - https://jidc.org/index.php/journal/article/view/24423718 SP - 094-100 AB - <p class="SmallText">Introduction: Enterovirus 71 (EV71) infections can cause hand, foot, and mouth disease (HFMD), which is a potentially fatal illness in children. Epidemics of HFMD are seen every year globally and present an increasing threat to public health worldwide.<strong> </strong></p> <p class="SmallText">Methodology: To identify potential severity markers for severe HFMD, laboratory findings and levels of eight serum cytokines in 143 EV71-infected patients in Beijing You’an Hospital were analyzed. Patients were grouped by disease severity: Mild (no severe complications) (n = 59), isolated isolated brainstem encephalitis (BE) (n = 47), isolated pulmonary edema (PE) (n = 12), and BE+PE (n = 25).<strong> </strong></p> <p class="SmallText">Results: IL-8 levels peaked at day one after admission and were found to be correlated to disease severity, maximal body temperature, and length of hospital stay. Among all tested cytokines, IL-8 was correlated to only IL-6 (p = 0.010). IL-6 and IL-10 were elevated in most patients (98.6% and 70.6%), but not correlated to disease severity (both p &gt; 0.05). IFNg was only negatively correlated to mild cases (p = 0.025).</p> <p class="SmallText">Conclusions: IL-8 was correlated to disease severity of HFMD. IL-6 and IL-10, although elevated in most HFMD patients, were not correlated to disease severity.</p> ER -