TY - JOUR AU - Senbayrak Akcay, Seniha AU - Inan, Asuman AU - Cevan, Simin AU - Ozaydın, Ayse Nilufer AU - Cobanoglu, Naz AU - Ozyurek, Seyfi Celik AU - Aksaray, Sebahat PY - 2014/05/14 Y2 - 2024/03/29 TI - Gram-negative bacilli causing infections in an intensive care unit of a tertiary care hospital in Istanbul, Turkey JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 8 IS - 05 SE - Original Articles DO - 10.3855/jidc.4277 UR - https://jidc.org/index.php/journal/article/view/24820463 SP - 597-604 AB - <p class="SmallText">Introduction: This study aimed to demonstrate the changing epidemiology of infecting microorganisms and their long-term resistance profiles and to describe the microbiological point of view in anti-infective management of intensive care unit (ICU) patients.</p> <p class="SmallText">Methodology: A total of 5,690 isolates of Gram-negative bacilli were included in this study. Antibiotic susceptibility was tested using the disk diffusion method and Vitek 2 system. Chi-square tests were used for hypothesis testing.</p> <p class="SmallText">Results: The most frequently isolated organisms were <em>A. baumannii </em>(37.3%), <em>P. aeruginosa </em>(30.3%), <em>Enterobacter </em>spp.<em> </em>(10.4%), <em>E. coli </em>(10.4%), and <em>Klebsiella </em>spp.<em> </em>(8.9%). <em>A. baumannii </em>was the most frequently isolated organism from the respiratory tract (43.4%); the susceptibility rates for imipenem and meropenem decreased to 7% and 6% (p &lt; 0.0001), respectively. The percentage of multidrug-resistant (MDR) <em>A. baumannii</em> isolates<em> </em>continuously increased from 18.7% in 2004 to 69% in 2011 (p &lt; 0.0001), whereas MDR <em>P. aeruginosa </em>isolates increased from 1.5% to 22% (p &lt; 0.0001). Carbapenem-resistant <em>Klebsiella </em>isolates emerged in 2010 and increased to 20% in the next year. The rates of ESBL-producing <em>Enterobacteriaceae</em> in the ICU was very high in 2011 – 50% for <em>E. coli</em> and 80% for <em>Klebsiella </em>strains.</p> <p class="SmallText">Conclusion: The most common isolated Gram-negative bacillus in our study was <em>A. baumannii </em>and<em> </em>that the prevalence of MDR isolates has increased markedly over. Accordingly, the comparison of antibiotic resistance of other pathogens in 2004 and 2011 displayed an increasing trend. These data imply the urgent need for new and effective strategies in our hospital and in the region.</p> ER -