TY - JOUR AU - Zhu, Huijuan AU - Liu, Xingxiang AU - Xue, Yong AU - Shen, Chong AU - Li, Yinghui AU - Wang, Aili AU - Ding, Yi AU - Zheng, Zhi AU - Dong, Chen PY - 2015/05/18 Y2 - 2024/03/28 TI - Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 9 IS - 05 SE - Original Articles DO - 10.3855/jidc.5416 UR - https://jidc.org/index.php/journal/article/view/25989171 SP - 512-518 AB - <p class="SmallText">Introduction: This study aimed to analyze the characteristics of HBsAg, HBsAb, coexistence of HBsAg and HBsAb, and the genotypic distribution of HBV in Chinese schizophrenia patients.</p> <p class="SmallText">Methodology: A total of 1,694 schizophrenia patients, 9-85 years of age, were recruited for the present study. HBsAg, HBsAb, and HBV DNA were detected with commercial methods. ALT, AST, γ-GT, TBIL, and IBIL were measured by an automatic biochemistry analyzer. All statistical analyses were performed with SPSS 13.0.</p> <p class="SmallText">Results: The seroprevalence of HBsAg and HBsAb in 1,649 schizophrenia patients was 11.0% and 54.6%, respectively. HBsAb seroprevalence significantly decreased with the duration of the disease (p = 0.0009). The lowest seroprevalence of HBsAg was determined in 9.4% of the patients who had had the illness for &lt; 1 year, and then increased to 11.7%, 11.3% and 11.7% in the patients who had had the illness for 1–5 years, 6–10 years and &gt; 10 years. HBsAg and HBsAb coexisted in 69 individuals, which comprised 4.2% of the total subjects, and in 38.1% of the HBsAg-positive patients. Additionally, HBV titers were quantified in 64 HBsAg-positive samples; the highest virus titer was 6.14×10<sup>8</sup> copies/mL, while 12 patients had less than 500 copies/mL. Moreover, among 48 HBV strains isolated from 62 HBsAg-positive samples, 33 and 15 strains belonged to genotypes C and B, respectively.</p> <p class="SmallText">Conclusion: Genotypes B and C HBV were the dominant genotypes distributed in schizophrenia patients, and the HBsAb seroprevalence significantly decreased with illness duration. Effective prevention strategies for against HBV transmission are required.</p> ER -