TY - JOUR AU - Cui, Yali AU - Huang, Xiaocui AU - Wang, Xia AU - Li, Yingying AU - Tang, Chao AU - Wang, Hong AU - Jiang, Yongmei PY - 2017/04/30 Y2 - 2024/03/29 TI - Correlation between infection of herpes virus family and liver function parameters: a population-based cross-sectional study JF - The Journal of Infection in Developing Countries JA - J Infect Dev Ctries VL - 11 IS - 04 SE - Original Articles DO - 10.3855/jidc.8089 UR - https://jidc.org/index.php/journal/article/view/28459223 SP - 320-325 AB - <p class="SmallText">Introduction: To evaluate the relationship between seropositivity to herpes virus family and liver function parameters in children from southwest China.</p> <p class="SmallText">Methodology: A 2-year cross-sectional retrospective study of 6,396 children aged 6 months to 12 years was performed. All participants underwent physical examination and liver function tests.</p> <p class="SmallText">Results: Of the children, 622 were positive for EBV, HSV, or CMV IgM, with dramatic changes in liver function parameters. Aspartate aminotransferase and alanine aminotransferase levels were negatively correlated with EBV-IgM and hepatocellular injuries in children &lt; 3 years of age, whereas a positive correlation between lactate dehydrogenase (LDH) and EBV-IgM and hepatocellular injuries was documented in children &lt; 1 year of age. In those &lt; 1 year and 3–6 years of age, HSV-IgM seropositivity was positively correlated with indirect bilirubin and γ-glutamyl transferase. The percentage of children &lt; 1 year of age with positive CMV-IgM was 72.8% (158/217), approximately five times higher than that in those 1–3 years. Sixty-three children were infected with two pathogens simultaneously. Abnormal levels of LDH were observed in 85.71% of children simultaneously infected with CMV and HSV, 77.78% for CMV and EBV, 83.33% for EBV and HSV, and irregular levels of AST were noted in 69.19% of children infected with CMV and HSV, 77.78% for CMV and EBV, and 83.33% for EBV and HSV.</p> <p class="SmallText">Conclusions: Seropositivity to herpes virus family was correlated with abnormal liver function parameters across years of age. Clinicians should aim to protect the liver function of children infected with herpes viruses.</p> ER -