Using next generation sequencing to tackle non-typhoidal Salmonella infections

John Wain; Karen H Keddy; Rene S Hendriksen; Salvatore Rubino

doi:10.3855/jidc.3080

Using next generation sequencing to tackle non-typhoidal Salmonella infections

Authors

John Wain Norwich Medical School, University of East Anglia, Norwich, UK
Karen H Keddy Centre for Enteric Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg.
Rene S Hendriksen WHO Collaborating Centre for antimicrobial resistance in foodborne pathogens and European Union Reference Laboratory for antimicrobial resistance, National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
Salvatore Rubino Departimento di Scienze Biomediche, Center for Biotechnology Development and Biodiversity Research, University of Sassari, Sassari.

DOI:

https://doi.org/10.3855/jidc.3080

Keywords:

Salmonella Typhimurium ST313, non-typhoidal Salmonella, next generation sequencing

Abstract

The publication of studies using next generation sequencing to analyse large numbers of bacterial isolates from global epidemics is transforming microbiology, epidemiology and public health. The emergence of multidrug resistant Salmonella Typhimurium ST313 is one example. While the epidemiology in Africa appears to be human-to-human spread and the association with invasive disease almost absolute, more needs to be done to exclude the possibility of animal reservoirs and to transfer the ability to track all Salmonella infections to the laboratories in the front line. In this mini-review we summarise what is currently known about non-typhoidal Salmonella in sub-Saharan Africa and discuss some of the issues which remain.

Author Biography

John Wain, Norwich Medical School, University of East Anglia, Norwich, UK

Professor of Microbiology, School of Medicine.

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Published

2013-01-15

How to Cite

Wain J, Keddy KH, Hendriksen RS, Rubino S (2013) Using next generation sequencing to tackle non-typhoidal Salmonella infections. J Infect Dev Ctries 7:001–005. doi: 10.3855/jidc.3080

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Issue

Vol. 7 No. 01: January 2013

Section

Reviews

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