Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patients

Mosin S Khan; Abid Shoukat; Syed Mudassar; Zaffar Kawoosa; Altaf H Shah; Showkat Ali Zargar

doi:10.3855/jidc.10175

Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patients

Authors

Mosin S Khan Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India
Abid Shoukat Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India
Syed Mudassar Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India
Zaffar Kawoosa Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India
Altaf H Shah Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India
Showkat Ali Zargar Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India

DOI:

https://doi.org/10.3855/jidc.10175

Keywords:

Hepatitis C, chronic hepatitis C, IL28B, viral genotype, PCR-RFLP, hepatocellular carcinoma

Abstract

Introduction: Viral genotype and variation in host genes involved in the immune response may predict the treatment response in patients infected with HCV. The present study was designed to determine the distribution pattern of HCV and host genotypes in Chronic Hepatitis C (CHC) patients and their association with virological response and other risk factors.

Methodology: Two hundred and fifty (n = 250) HCV positive patients were included in the study. HCV and Interleukin 28B (IL28B) genotyping was carried out by PCR-RFLP.

Results: Viral genotype 3 was the predominant genotype seen in 187 (74.8%) patients. Wild genotype predominated in rs12979860, rs12980275 and rs8099917 SNP of IL28B gene. A significant difference was found in end stage virological response (EVR) between HCV genotype 1 infected patients with wild and variant genotype for rs12980275 and rs8099917 SNPs respectively (P < 0.05). On multivariate analysis all the SNPs were found to be associated with each other (P < 0.05) with rs12980275 SNP associated with history of Jaundice (P < 0.05). Viral genotype 3 was significantly associated with age (< 50 years) and rapid virological response (RVR) while as viral genotype 1 was significantly associated with history of surgery on multivariate analysis (P < 0.05).

Conclusions: The viral genotype and IL28B polymorphisms are important factors to personalize antiviral therapy of patients with CHC.

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Published

2018-09-30

How to Cite

Khan MS, Shoukat A, Mudassar S, Kawoosa Z, Shah AH, Zargar SA (2018) Impact of IL28B genetic variant’s and viral genotype on treatment outcome of hepatitis C infected patients. J Infect Dev Ctries 12:762–770. doi: 10.3855/jidc.10175

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Issue

Vol. 12 No. 09: September 2018

Section

Original Articles

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