A new approach to the treatment of acute infection diseases with antibiotic-pectin formulae

Zayniddin K Muhidinov; Jamshed T Bobokalonov; Rahimjon S Kimatov; Erkin R Rahmonov; Gulnora I Komilova; Zamira U Sherova; LinShu Liu

doi:10.3855/jidc.18473

A new approach to the treatment of acute infection diseases with antibiotic-pectin formulae

Authors

Zayniddin K Muhidinov Chemistry Institute of the National Academy of Sciences of Tajikistan, Dushanbe, Tajikistan https://orcid.org/0000-0002-0023-2229
Jamshed T Bobokalonov Chemistry Institute of the National Academy of Sciences of Tajikistan, Dushanbe, Tajikistan https://orcid.org/0000-0002-0829-9364
Rahimjon S Kimatov Avicenna Tajik Medical University, Dushanbe, Tajikistan
Erkin R Rahmonov Avicenna Tajik Medical University, Dushanbe, Tajikistan
Gulnora I Komilova Avicenna Tajik Medical University, Dushanbe, Tajikistan
Zamira U Sherova Chemistry Institute of the National Academy of Sciences of Tajikistan, Dushanbe, Tajikistan
LinShu Liu Eastern Regional Research Center, ARS, USDA, Wyndmoor, PA 19038, United States

DOI:

https://doi.org/10.3855/jidc.18473

Keywords:

amebiasis, dysentery, pectin, metronidazole, ciprofloxacin, tetracycline

Abstract

Introduction: Intestinal infections are a significant health issue; antibiotics are essential in treating acute intestinal infections. However, evidence in the literature shows that the excessive use of antibiotics has created many threats to human health. This work aimed to study the impact of apple pectin in combination with antibiotics on treating patients with amebiasis and dysentery.

Methodology: Patients suffering from acute intestinal diseases (amebiasis and dysentery) were treated with traditional antibiotic therapy and a new formula containing antibiotics with low and high methoxylated apple pectin in a randomized block design. Four clinical trials were performed at the Infection Disease Hospital from 1998 until 2013.

Results: The study demonstrated that the antibiotic-pectin formulae (APF) significantly reduced the severity of acute intestinal infection diseases and allowed patients to recover faster than conventional treatment. APF reduced the patient’s stay in the hospital by 3.0 ± 1.0 days. The clinical trial findings demonstrated that applying APF in intestinal infection diseases helped maintain a constant concentration of the antibiotic in the blood and accelerated the clinical recovery of the patients.

Conclusions: It was concluded that using pectin with antibiotics could improve clinical outcomes in patients with acute infectious diseases. Research on elucidating the mechanisms of pectin digestion in the colon, polyphenol content, and its role in dysbiosis recovery, etc., is also considered.

Author Biographies

Jamshed T Bobokalonov, Chemistry Institute of the National Academy of Sciences of Tajikistan, Dushanbe, Tajikistan

Ph.D., Lead scientist, pharmacist, Fulbright scholar 2017-2019 at Eastern Reginal Research Center of ARS USDA, Philadelphia, PA, the USA.

Rahimjon S Kimatov, Avicenna Tajik Medical University, Dushanbe, Tajikistan

The assistance of professor at the Department of Infection Diseases in the Avicenna Tajik Medical University, Dushanbe, Tajikistan

Erkin R Rahmonov, Avicenna Tajik Medical University, Dushanbe, Tajikistan

MD, professor, head of the Infection Diseases Department at the Avicenna Tajik Medical University, Dushanbe, Tajikistan

Gulnora I Komilova, Avicenna Tajik Medical University, Dushanbe, Tajikistan

Microbiologist, Department of Infection Diseases at the Avicenna Tajik Medical University, Dushanbe, Tajikistan

LinShu Liu, Eastern Regional Research Center, ARS, USDA, Wyndmoor, PA 19038, United States

Dr. Professor, Research Chemist at the Dairy and Functional Foods Research: ERRC ARS USDA, Wyndmoor, PA. Research Collaborator.

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Published

2024-03-31

How to Cite

Muhidinov ZK, Bobokalonov JT, Kimatov RS, Rahmonov ER, Komilova GI, Sherova ZU, Liu L (2024) A new approach to the treatment of acute infection diseases with antibiotic-pectin formulae. J Infect Dev Ctries 18:407–419. doi: 10.3855/jidc.18473

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Issue

Vol. 18 No. 03: March 2024

Section

Original Articles

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