Hematological profile among cutaneous leishmaniasis patients before and after treatment with sodium stibogluconate in Diyala, Iraq

Ghuffran Muhammed Hassan; Hayder Z Ali; Watheq Muhammed Hussein

doi:10.3855/jidc.18962

Hematological profile among cutaneous leishmaniasis patients before and after treatment with sodium stibogluconate in Diyala, Iraq

Authors

Ghuffran Muhammed Hassan Department of Biology, College of Science, University of Baghdad, Al-Jaderiya Campus, Baghdad, Iraq https://orcid.org/0000-0003-4981-0832
Hayder Z Ali Department of Biology, College of Science, University of Baghdad, Al-Jaderiya Campus, Baghdad, Iraq https://orcid.org/0000-0002-9265-8971
Watheq Muhammed Hussein Dermatology department, University of Diyala College of Medicine, Diyala governorate, Baquba, Iraq

DOI:

https://doi.org/10.3855/jidc.18962

Keywords:

Cutaneous leishmaniasis, sodium stibogluconate, CBC, anti-leishmanial IgG, Iraq

Abstract

Introduction: Cutaneous leishmaniasis (CL) is a common protozoan disease in Iraq characterized by localized ulcers, primarily on exposed skin. This study aimed to investigate the hematological parameters of infected patients using a complete blood count (CBC) in the endemic area of Diyala Governorate, northeast of Baghdad. This has been studied in newly diagnosed, untreated individuals and patients receiving sodium antimony gluconate.

Methodology: Hematological screening was performed on blood samples from 161 patients with microscopically diagnosed cutaneous leishmaniasis before and after treatment. Anti-Leishmania IgG was also assessed by ELISA in seropositive and seronegative subjects.

Results: The newly diagnosed, untreated patients showed no significant differences in blood cell counts, whereas treated patients had significant changes in white blood cell composition, including absolute neutrophil count (ANC), absolute monocytes (MID), eosinophils Granulocytes and Neutrophil-Lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), platelets count (PLT) and Mean Platelets Volume (MPV), following the administration of five consecutive sodium stibogluconate injection. In addition, the anti-Leishmania IgG seroprevalence was highest (85%) in the newly diagnosed, untreated group and gradually decreased with continued treatment. However, there was no significant difference in red blood cell components including red blood cells (RBC), hematocrit test (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW) before and after treatment.

Conclusions: The current data gave an insight into certain hematological factors regarding WBC subtypes, along with cutaneous leishmaniasis treatment. In addition, the anti-Leishmania IgG may be considered a marker for therapeutic monitoring.

Author Biographies

Ghuffran Muhammed Hassan, Department of Biology, College of Science, University of Baghdad, Al-Jaderiya Campus, Baghdad, Iraq

PhD Student

Watheq Muhammed Hussein, Dermatology department, University of Diyala College of Medicine, Diyala governorate, Baquba, Iraq

Dermatologist

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Published

2024-11-30

How to Cite

Hassan GM, Ali HZ, Hussein WM (2024) Hematological profile among cutaneous leishmaniasis patients before and after treatment with sodium stibogluconate in Diyala, Iraq. J Infect Dev Ctries 18:1772–1779. doi: 10.3855/jidc.18962

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Issue

Vol. 18 No. 11: November 2024

Section

Original Articles

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