Dam and its role in pathogenicity of Salmonella enterica

Mónica N. Giacomodonato; Sebastián H. Sarnacki; Mariángeles Noto Llana; M. Cristina Cerquetti

doi:10.3855/jidc.465

Dam and its role in pathogenicity of Salmonella enterica

Authors

Mónica N. Giacomodonato Centro de Estudios Farmacológicos y Botánicos CEFyBO-CONICET, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires
Sebastián H. Sarnacki Centro de Estudios Farmacológicos y Botánicos CEFyBO-CONICET, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires
Mariángeles Noto Llana Centro de Estudios Farmacológicos y Botánicos CEFyBO-CONICET, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires
M. Cristina Cerquetti Centro de Estudios Farmacológicos y Botánicos CEFyBO-CONICET, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires

DOI:

https://doi.org/10.3855/jidc.465

Keywords:

DNA adenine methylase, Pathogenesis, Salmonella enterica

Abstract

Dam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy for the generation of vaccines against bacterial pathogens. In this review, we focus our attention on the role of methylation by Dam protein in regulating bacterial gene expression and virulence in Salmonella enterica.

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Published

2009-08-30

How to Cite

Giacomodonato MN, Sarnacki SH, Llana MN, Cerquetti MC (2009) Dam and its role in pathogenicity of Salmonella enterica. J Infect Dev Ctries 3:484–490. doi: 10.3855/jidc.465

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Issue

Vol. 3 No. 07: August 2009

Section

Reviews

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