Polyclonal dissemination of tetracycline resistance among Streptococcus pyogenes paediatric isolates from Brazil

Pierre Robert Smeesters; Sabina Cadar; Pierre-Alexandre Drèze; Dioclécio Campos; Laurence Van Melderen

doi:10.3855/jidc.1138

Polyclonal dissemination of tetracycline resistance among Streptococcus pyogenes paediatric isolates from Brazil

Authors

Pierre Robert Smeesters Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Belgium
Sabina Cadar Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Belgium
Pierre-Alexandre Drèze Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Belgium
Dioclécio Campos Hospital Universitário de Brasília, Universidade de Brasília, Brazil
Laurence Van Melderen Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, Belgium

DOI:

https://doi.org/10.3855/jidc.1138

Keywords:

tetracycline resistance, minocycline resistance, emm gene, GAS phylogeny

Abstract

Introduction: Scarce data are available on Group A Streptococcus (GAS) antibiotic resistance in South America.

Methodology: The antibiotic susceptibility patterns of GAS recovered from symptomatic children living in the central part of Brazil during a prospective epidemiological study were analyzed.

Results: No isolates were resistant to penicillin or macrolides. Sixty-one percent of the isolates were highly resistant to tetracycline, of which 85% harboured the tetM resistance gene. Ninety-five percent of these tetracycline resistant isolates were also resistant to minocycline. Thirty different emm-types were associated with tetracycline resistance. Phylogenetic analysis indicates that tetracycline resistance arose independently in distantly related emm-types.

Conclusions: A high level of GAS tetracycline resistance has been observed in the central part of Brazil due to the polyclonal dissemination of resistant emm-types.

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Published

2010-07-19

How to Cite

Smeesters PR, Cadar S, Drèze P-A, Campos D, Van Melderen L (2010) Polyclonal dissemination of tetracycline resistance among Streptococcus pyogenes paediatric isolates from Brazil. J Infect Dev Ctries 4:704–711. doi: 10.3855/jidc.1138

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Issue

Vol. 4 No. 11: November 2010

Section

Original Articles

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