Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in Ethiopia

  • Getenet Beyene Department of Medical Microbiology, Immunology and Parasitology, Jimma, University,
  • Satheesh Nair Laboratory for Gastrointestinal Pathogens, HPA, Colindale
  • Daniel Asrat Department of Medical Microbiology, Immunology and Parasitology, Addis Ababa, University
  • Yohannes Mengistu Department of Medical Microbiology, Immunology and Parasitology, Addis Ababa, University
  • Howard Engers Armauer Hansen Research Institute, Addis Ababa, Ethiopia
  • John Wain Laboratory for Gastrointestinal Pathogens, HPA, Colindale
Keywords: Salmonella, Concord, antibiotic resistance, antimicrobial agents, Ethiopia

Abstract

Introduction: S. Concord in Ethiopia. The objective of this study was to determine the aetiology of febrile and diarrhoeic illness in Ethiopian children focussing on Salmonella.

Methodology: Paediatric patients (n = 1,225) presenting with diarrhoea or fever from the paediatric outpatient department of Tikur Anbessa University Hospital, Addis Ababa (n = 825), and Jimma University Hospital, South West Ethiopia (n = 400), were investigated for pathogens from January to August 2006.

Results: Parasites were detected in 337 cases, Salmonella in 65, and Shigella in 61. Serotyping of Salmonella (including 48 stored isolates) demonstrated the dominance of S. Concord:  S. Concord (85), S. Typhimurium (7), S. Paratyphi B (2), S. Haifa (1), S. Typhi (2),  S. Enteritidis (4), S. Butantan (2), S. Infantis (1), S. Pomona (1), Salmonella group M (28:y:-)  (1), and S. Oskarshamn (1). Six isolates in serogroups B and D were untypeable. Of 81 S. Concord isolates, 30% were invasive, most (86.5%) were positive for ESBL production by E-test and 70% were multiply resistant to trimethoprim-sulphamethaxole, ceftriaxone, chloramphenicol and gentamicin, of which over one quarter (27%) also showed reduced susceptibility to ciprofloxacin.

Conclusion: Multi-drug resistant S. Concord was the major cause of salmonellosis in two regions of Ethiopia. The strain isolated was highly invasive, highly antibiotic-resistant, and represents a threat to heath care globally.

Author Biographies

Getenet Beyene, Department of Medical Microbiology, Immunology and Parasitology, Jimma, University,
Lecturer, Jimma University, Jimma
Satheesh Nair, Laboratory for Gastrointestinal Pathogens, HPA, Colindale
Senior scientists, LGP, Colindale, UK
John Wain, Laboratory for Gastrointestinal Pathogens, HPA, Colindale

Head of Laboratory Services, GEZI

Published
2011-01-31
How to Cite
1.
Beyene G, Nair S, Asrat D, Mengistu Y, Engers H, Wain J (2011) Multidrug resistant Salmonella Concord is a major cause of salmonellosis in children in Ethiopia. J Infect Dev Ctries 5:023-033. doi: 10.3855/jidc.906
Section
Original Articles