Distribution of HIV-1 and HSV-2 epidemics in Chad revealing HSV-2 hot-spot in regions of high-risk HIV spread

Authors

  • Charlotte Charpentier Laboratoire de Virologie, Hôpital Européen Georges Pompidou, and Faculté de Médecine Paris Descartes, Paris, France
  • Donato Koyalta Hôpital Général de Référence Nationale, N’Djamena, Chad
  • Montana Ndinaromtan Hôpital Général de Référence Nationale, N’Djamena, Chad
  • Bagamla Tchobkréo Institut National de la Statistique, des Etudes Economiques et Démographiques, N’Djamena
  • Mohammad-Ali Jenabian Laboratoire de Virologie, Hôpital Européen Georges Pompidou, and Faculté de Médecine Paris Descartes, Paris, France
  • Nesrine Day Laboratoire de Virologie, Hôpital Européen Georges Pompidou, and Faculté de Médecine Paris Descartes, Paris, France
  • Ali Si-Mohamed Laboratoire de Virologie, Hôpital Européen Georges Pompidou, and Faculté de Médecine Paris Descartes, Paris, France
  • Helen Weiss London School of Hygiene and Tropical Medicine, London, U.K.
  • Laurent Bélec Laboratoire de Virologie, Hôpital Européen Georges Pompidou, and Faculté de Médecine Paris Descartes, Paris, France

DOI:

https://doi.org/10.3855/jidc.1054

Keywords:

HIV-1, HSV-2, Chad, ecologic analysis, refugees

Abstract

Introduction: Herpes Simplex Virus-2 (HSV-2) is known to be a potent co-factor of Human Immunodeficiency type 1 virus (HIV-1) heterosexual transmission. We were interested in assessing the distribution of HIV-1 and HSV-2 epidemics at the national level in Chad.

Methodology: In 2007, a population-based anonymous serosurvey for HIV-1 and HSV-2 infections, using dried blood spots, was conducted. The study included 548 adults living in 15 regions of Chad. After specimen elution, serological testing for HIV and HSV-2 infections was performed.

Results: Countrywide, the HIV-1 and HSV-2 seroprevalences were 11.1% and 15.7%, respectively. A positive correlation was observed with the highest HIV-1 prevalence seen in regions of the highest HSV-2 prevalence, especially in two conflict-affected eastern provinces of Darfur.

Conclusion: Urgent public health interventions are needed in regions of Chad where high HSV-2 prevalence may be increasing the risk of HIV propagation.

Author Biographies

Charlotte Charpentier, Laboratoire de Virologie, Hôpital Européen Georges Pompidou, and Faculté de Médecine Paris Descartes, Paris, France

Donato Koyalta, Hôpital Général de Référence Nationale, N’Djamena, Chad

Bagamla Tchobkréo, Institut National de la Statistique, des Etudes Economiques et Démographiques, N’Djamena

Helen Weiss, London School of Hygiene and Tropical Medicine, London, U.K.

 

Laurent Bélec, Laboratoire de Virologie, Hôpital Européen Georges Pompidou, and Faculté de Médecine Paris Descartes, Paris, France

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Published

2010-08-31

How to Cite

1.
Charpentier C, Koyalta D, Ndinaromtan M, Tchobkréo B, Jenabian M-A, Day N, Si-Mohamed A, Weiss H, Bélec L (2010) Distribution of HIV-1 and HSV-2 epidemics in Chad revealing HSV-2 hot-spot in regions of high-risk HIV spread. J Infect Dev Ctries 5:064–067. doi: 10.3855/jidc.1054

Issue

Vol. 5 No. 01: January 2011

Section

Brief Original Articles

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