Clinical characteristics and predictors of mortality in hospitalized HIV-infected Nigerians

Authors

  • Patricia Aladi Agaba AIDS Prevention Initiative Nigeria Plus, Jos University Teaching Hospital, Nigeria
  • Eunice Digin AIDS Prevention Initiative Nigeria Plus, Jos University Teaching Hospital, Nigeria
  • Rahila Makai AIDS Prevention Initiative Nigeria Plus, Jos University Teaching Hospital, Nigeria
  • Labake Apena AIDS Prevention Initiative Nigeria Plus, Jos University Teaching Hospital, Nigeria
  • Oche O Agbaji Department of Medicine, University of Jos, Nigeria
  • John A Idoko Department of Medicine, University of Jos, Nigeria
  • Rob Murphy Division of Infectious Diseases, Northwestern University Medical School, Chicago IL, USA
  • Phyllis Kanki Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA

DOI:

https://doi.org/10.3855/jidc.1096

Keywords:

Characteristics, mortality, hospitalized, HIV-infected, Nigerians

Abstract

Introduction: Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a chief cause of death in sub-Saharan Africa. In this study, the clinical characteristics and predictors of mortality among hospitalized HIV infected adult Nigerians are reported.

Methodology: The records of 354 patients were reviewed for demographic and clinical characteristics. Predictors of mortality using logistic regression in a retrospective study were also reviewed.

Results: A total of 109 (30.8%) males and 245 (69.2%) females participated in the study. The mean age of all participants was 35 ± 8 years. Median baseline CD4 cell counts and viral load were 91 cells/mm³ and 63,438 copies/ml respectively. There was a total of 123 (34.8%) deaths while 231 (65.2%) patients were discharged home. Tuberculosis (TB) was the most common diagnosis on admission as well as the leading cause of death. Among all subjects, only male gender (adjusted odds ratio [AOR] 4.67, 95% confidence interval [CI]: 2.63-8.29); CD4 cell count ≤ 200 cells/mm3 (AOR 5.28, 95% CI: 2.99-9.31); length of hospital stay < 3 days (AOR 4.77, 95% CI: 1.35-16.86); and age ≥ 35 years (AOR 2.43, 95% CI: 1.41-4.19) were predictive of death.

Conclusion: These findings illustrate the need for early diagnosis of HIV infection, appropriate treatment and prevention of opportunistic infections, and improved access to highly active antiretroviral therapy (HAART).

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Published

2011-03-04

How to Cite

1.
Agaba PA, Digin E, Makai R, Apena L, Agbaji OO, Idoko JA, Murphy R, Kanki P (2011) Clinical characteristics and predictors of mortality in hospitalized HIV-infected Nigerians. J Infect Dev Ctries 5:377–382. doi: 10.3855/jidc.1096

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Section

Original Articles