Developing live vaccines against plague

  • Wei Sun Center for Infectious Disease and Vaccinology, The Biodesign Institute and School of Life Sciences, Arizona State University. Tempe, AZ, 85287, USA
  • Kenneth L Roland Center for Infectious Disease and Vaccinology, The Biodesign Institute and School of Life Sciences, Arizona State University. Tempe, AZ, 85287, USA
  • Roy Curtiss III Center for Infectious Disease and Vaccinology, The Biodesign Institute and School of Life Sciences, Arizona State University. Tempe, AZ, 85287, USA
Keywords: Yersinia pestis, plague, live vaccines

Abstract

Three great plague pandemics caused by the gram-negative bacterium Yersinia pestis have killed nearly 200 million people and it has been linked to biowarfare in the past. Plague is endemic in many parts of the world. In addition, the risk of plague as a bioweapon has prompted increased research to develop plague vaccines against this disease. Injectable subunit vaccines are being developed in the United States and United Kingdom.  However, the live attenuated Y. pestis-EV NIIEG strain has been used as a vaccine for more than 70 years in the former Soviet Union and in some parts of Asia and provides a high degree of efficacy against plague.  This vaccine has not gained general acceptance because of safety concerns.  In recent years, modern molecular biological techniques have been applied to Y. pestis to construct strains with specific defined mutations designed to create safe, immunogenic vaccines with potential for use in humans and as bait vaccines to reduce the load of Y. pestis in the environment.  In addition, a number of live, vectored vaccines have been reported using attenuated viral vectors or attenuated Salmonella strains to deliver plague antigens. Here we summarize the progress of live attenuated vaccines against plagu
Published
2011-05-22
How to Cite
1.
Sun W, Roland KL, Curtiss III R (2011) Developing live vaccines against plague. J Infect Dev Ctries 5:614-627. doi: 10.3855/jidc.2030
Section
Reviews