OXA-type carbapenemases in Acinetobacter baumannii in South America

Authors

  • Andrés Opazo Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile
  • Mariana Domínguez Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile
  • Helia Bello Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile
  • Sebastian G.B. Amyes Molecular Chemotherapy, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
  • Gerardo González-Rocha Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile

DOI:

https://doi.org/10.3855/jidc.2310

Keywords:

Acinetobacter baumannii, carbapenem-resistance, OXA-type carbapenemases, South America, Chile

Abstract

Acinetobacter baumannii is an opportunistic pathogen that is frequently involved in outbreaks of infection, occurring mostly in intensive care units. The increasing incidence of carbapenem resistance in A. baumannii worldwide is a concern since it limits drastically the range of therapeutic alternatives. The most important mechanism of carbapenem resistance is the enzymatic hydrolysis mediated by carbapenemases. In A. baumannii these enzymes are usually OXA-type carbapenemases, and belong to class D according to the classification of Ambler. The OXA-type carbapenemases are divided into five subgroups, four of which correspond to acquired carbapenemases, which accounts for the distribution of genes blaOXA in different geographic areas. In this work we review the different types of OXA-type carbapenemases present in A. baumannii, emphasizing the current situation in South America with special mention to the findings in Chile.

Author Biographies

Andrés Opazo, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile

PhD Studente at

Molecular Chemotherapy, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, UK.

Mariana Domínguez, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile

Assistant Profesor in Microbiology

Department of Microbiology. Faculty of Biological Sciences

Helia Bello, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile

Associate Profesor in Microbiology

Department of Microbiology. Faculty of Biological Sciences

Sebastian G.B. Amyes, Molecular Chemotherapy, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom

Full Professor

Molecular Chemotherapy, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, UK

Gerardo González-Rocha, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile

Associate Profesor in Microbiology

Department of Microbiology. Faculty of Biological Sciences

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Published

2011-12-24

How to Cite

1.
Opazo A, Domínguez M, Bello H, Amyes SG, González-Rocha G (2011) OXA-type carbapenemases in Acinetobacter baumannii in South America. J Infect Dev Ctries 6:311–316. doi: 10.3855/jidc.2310

Issue

Vol. 6 No. 04: April 2012

Section

Reviews

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