Pregnancy and H1N1 infection in Southeast Turkey

  • Hatice Ender Soydinc Dicle University School of Medicine, 21280, Diyarbakir, Turkey
  • Mustafa Kemal Celen Dicle University School of Medicine, 21280, Diyarbakir, Turkey
  • Bahri Yıldız Dicle University School of Medicine, 21280, Diyarbakir, Turkey
  • Muhammet Erdal Sak Dicle University School of Medicine, 21280, Diyarbakir, Turkey
  • Mehmet Sıddık Evsen Dicle University School of Medicine, 21280, Diyarbakir, Turkey
  • Talip Gul Dicle University School of Medicine, 21280, Diyarbakir, Turkey
Keywords: Influenza A virus, H1N1 subtype, pregnancy

Abstract

Introduction: H1N1 Influenza made a great impact a worldwide, as well as in Turkey, in 2009. Clinical experiences have shown that it had a more serious prognosis in pregnant women. In this report, we summarize the cases of 16 pregnant women with H1N1 Influenza.

Methodology: The study included 16 pregnant women hospitalized in Dicle University Hospital with complaints of fever, sore throat, cough and myalgia between October and December 2009. The diagnosis of pandemic H1N1 Influenza was confirmed on nasopharyngeal specimens using real-time reverse-transcriptase polymerase chain reaction (RT-PCR) in all patients. Patients who had the same complaints but were not diagnosed as H1N1 Influenza were excluded. The epidemiological, clinical, diagnostic, and outcome features of the patients were recorded.

Results: The median age of the patients was 27 years (range 18-41 years). The mean gestational age was 25.4 weeks (range 5-38 weeks). Two cases were twin pregnancy. Two cases had co-morbid diseases including asthma and anemia. The most frequent admission symptoms were fever in 13 cases (81%), cough in 12 cases (75%) and dyspnea in 6 cases (37,5%). Antiviral treatment (oseltamivir 75 mg p.o. bid) was applied in 15 cases. Four cases needed intensive care monitoring and two of them died (12.5%) because of severe respiratory insufficiency.

Conclusion: Patients with late gestational age, the presence of co-morbid disease, and multiple pregnancy have poor prognosis. Immediate intervention with antiviral treatment is associated with reduced severity of the disease and duration of hospital stay.

Author Biographies

Hatice Ender Soydinc, Dicle University School of Medicine, 21280, Diyarbakir, Turkey
Department of Gynecology and Obstetrics
Mustafa Kemal Celen, Dicle University School of Medicine, 21280, Diyarbakir, Turkey
Department of Infectious Diseases
Bahri Yıldız, Dicle University School of Medicine, 21280, Diyarbakir, Turkey
Department of Family Medicine
Muhammet Erdal Sak, Dicle University School of Medicine, 21280, Diyarbakir, Turkey
Department of Gynecology and Obstetrics
Mehmet Sıddık Evsen, Dicle University School of Medicine, 21280, Diyarbakir, Turkey
Department of Gynecology and Obstetrics
Talip Gul, Dicle University School of Medicine, 21280, Diyarbakir, Turkey
Department of Gynecology and Obstetrics
Published
2012-08-21
How to Cite
1.
Soydinc HE, Celen MK, Yıldız B, Sak ME, Evsen MS, Gul T (2012) Pregnancy and H1N1 infection in Southeast Turkey. J Infect Dev Ctries 6:644-649. doi: 10.3855/jidc.1956
Section
Original Articles