Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal

Aida Sadikh Badiane; Ousmane Sarr; Awa Bineta Deme; Ambroise Dioum Ahouidi; Papa Elhadji Omar Gueye; Mouhamadou Ndiaye; Mame Cheikh Seck; Mouhamadou Diallo; Amy Kristine Bei; Manoj T Duraisingh; Dyann Wirth; Daouda Ndiaye; Omar Ndir; Souleymane Mboup

doi:10.3855/jidc.2587

Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal

Authors

Aida Sadikh Badiane Universite Cheikh Anta Diop de Dakar, Dakar, Senegal
Ousmane Sarr Laboratoire de Bacteriologie virologie, Hopital A. Le Dantec, BP 7325, Dakar, Senegal
Awa Bineta Deme Laboratoire de Bacteriologie virologie, Hopital A. Le Dantec, BP 7325, Dakar, Senegal
Ambroise Dioum Ahouidi Laboratoire de Bacteriologie virologie, Hopital A. Le Dantec, BP 7325, Dakar, Senegal
Papa Elhadji Omar Gueye Laboratoire de Bacteriologie virologie, Hopital A. Le Dantec, BP 7325, Dakar, Senegal
Mouhamadou Ndiaye
Mame Cheikh Seck
Mouhamadou Diallo
Amy Kristine Bei Harvard School of Public Health, Boston, MA, USA
Manoj T Duraisingh Harvard School of Public Health, Boston, MA, USA
Dyann Wirth Harvard School of Public Health, Boston, MA, USA
Daouda Ndiaye Universite Cheikh Anta Diop de Dakar, Dakar, Senegal
Omar Ndir Universite Cheikh Anta Diop de Dakar, Dakar, Senegal
Souleymane Mboup Universite Cheikh Anta Diop de Dakar, Dakar, Senegal

DOI:

https://doi.org/10.3855/jidc.2587

Keywords:

Plasmodium falciparum, EBA-175, blood groups, Thies, Senegal

Abstract

Introduction: The study was conducted to determine for the first time the association between the erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in malaria patients living in Thies, a hypoendemic area in Senegal.

Methodology: In 2007, the EBA-175 alleles and blood group types were determined by nested PCR and the Simonin test respectively in blood samples obtained from uncomplicated Plasmodium falciparum malaria positive patients.

Results and conclusion: In total, 129 patients were enrolled in the study. The EBA-175 genotyping showed a prevalence of 67.45% for the F-allele, 27.90% for the C-allele and 4.65% of mixed C+F infection. The distribution of the ABO blood group type showed 59.8% for the O group, 19.7% for the A group, 17.2% for the B group, and 3.3% for the AB group. No correlation was noted between the EBA-175 alleles and either the blood group type or parasitemia.

Author Biographies

Aida Sadikh Badiane, Universite Cheikh Anta Diop de Dakar, Dakar, Senegal

Université Cheikh Anta Diop de Dakar Laboratoire de Parasitologie Mycologie,

Ousmane Sarr, Laboratoire de Bacteriologie virologie, Hopital A. Le Dantec, BP 7325, Dakar, Senegal

Molecular Biology Unit, Malaria Section, Laboratoire de Bacteriologie virologie, Hopital A. Le Dantec, BP 7325, Dakar, Senegal

Awa Bineta Deme, Laboratoire de Bacteriologie virologie, Hopital A. Le Dantec, BP 7325, Dakar, Senegal

Molecular Biology Unit, Malaria Section, Laboratoire de Bacteriologie virologie, Hopital A. Le Dantec, BP 7325, Dakar, Senegal

Ambroise Dioum Ahouidi, Laboratoire de Bacteriologie virologie, Hopital A. Le Dantec, BP 7325, Dakar, Senegal

Molecular Biology Unit, Malaria Section, Laboratoire de Bacteriologie virologie, Hopital A. Le Dantec, BP 7325, Dakar, Senegal

Dyann Wirth, Harvard School of Public Health, Boston, MA, USA

Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665

Huntington Avenue, Boston, MA, 02115

Daouda Ndiaye, Universite Cheikh Anta Diop de Dakar, Dakar, Senegal

Laboratoire de Parasitologie-Mycologie, Universite Cheikh Anta Diop de Dakar

Omar Ndir, Universite Cheikh Anta Diop de Dakar, Dakar, Senegal

Universite Cheikh Anta Diop De Dakar Laboratoire de Parasitologie Mycologie

Souleymane Mboup, Universite Cheikh Anta Diop de Dakar, Dakar, Senegal

Molecular Biology Unit, Malaria Section, Laboratoire de Bacteriologie virologie, Hopital A.

Le Dantec, BP 7325, Dakar, Senegal

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Published

2012-10-19

How to Cite

Badiane AS, Sarr O, Deme AB, Ahouidi AD, Gueye PEO, Ndiaye M, Seck MC, Diallo M, Bei AK, Duraisingh MT, Wirth D, Ndiaye D, Ndir O, Mboup S (2012) Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. J Infect Dev Ctries 6:727–733. doi: 10.3855/jidc.2587

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Issue

Vol. 6 No. 10: October 2012

Section

Original Articles

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