Enteric viral infections as potential risk factors for intussusception

  • Adel M Mansour US Naval Medical Research Unit No. 3, Bacteriology and Parasitology Diseases Research Program, Cairo, Egypt
  • Montasser El Koutby Pediatric Surgery department. Cairo University
  • Mohamed M El Barbary Paediatric Surgery Department, Cairo University
  • Wissam Mohamed Paediatric Surgery Department, Cairo University
  • Sameh Shehata Paediatric Surgery Department, Alexandria University
  • Hanan El Mohammady U.S.Naval Medical Research Unit-3
  • Manal Mostafa U.S.Naval Medical reserach Unit-3
  • Mark S Riddle U.S.Naval Medical Reserach Center
  • Peter J Sebeny U.S.Naval Medical Research Center
  • Sylvia Y.N. Young Navy Environmental and Preventive Medicine Unit 6
  • Ibrahim Abdel-Messih Novartis Vaccines and Diagnostics
Keywords: intussusception, adenovirus, rotavirus

Abstract

Introduction:  We aimed to identify potential risk factors for intussusception (ISS) among children presenting to two pediatric hospitals in Egypt.

Methodology: In this case-control study,  enrolled children < 3 years old with ISS (confirmed radiologically and/or surgically) were  matched by age and gender to controls admitted with acute non-abdominal surgical illnesses. Stool samples were collected and tested for various enteric bacteria, rotavirus, enteric adenoviruses (EA, 40 and 41) and astroviruses using commercially available ELISA diagnostic kits.

Results: From December 2004 to May 2009, 158 cases and 425 matched controls were enrolled. A history of diarrhoea and cough over the preceding four weeks of interview were more common in cases than controls, respectively. Children with mothers who had secondary education and above were 2.2 times more likely to have ISS than those whose mothers had a lower level of education. In spite of the low detection rate of EA infection (regardless of diarrhoea history) and asymptomatic rotavirus infection, they were detected in higher frequencies in cases than controls; however, infection with astrovirus and bacterial pathogens did not appear to be associated with increased risk of ISS.

Conclusions: History of diarrhoea and cough over the four weeks preceding the study and maternal education above secondary level were potential risk factors for ISS. EA and asymptomatic rotavirus infection were detected in higher frequencies among cases than controls; however, association with ISS cannot be confirmed. Additional research is needed to confirm these findings and evaluate the pathogenesis which may link such infections with ISS.

Published
2013-01-15
How to Cite
1.
Mansour AM, El Koutby M, El Barbary MM, Mohamed W, Shehata S, El Mohammady H, Mostafa M, Riddle MS, Sebeny PJ, Young SY, Abdel-Messih I (2013) Enteric viral infections as potential risk factors for intussusception. J Infect Dev Ctries 7:028-035. doi: 10.3855/jidc.2321
Section
Original Articles