Evaluation of methicillin-resistant Staphylococcus aureus nasal carriage in Malagasy patients

Authors

  • Tsiry Rasamiravaka Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar
  • Saida Rasoanandrasana Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar
  • Norosoa Julie Julie Zafindraibe Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar
  • Aimee Olivat Rakoto Alson Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar
  • Andry Rasamindrakotroka Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

DOI:

https://doi.org/10.3855/jidc.2460

Keywords:

MRSA, Malagasy lab, nasal carriage, risk factors

Abstract

Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of infections. It is well recognized that nasal carriage of S. aureus represents a potent and increasingly prevalent risk factor for subsequent S. aureus infection. However, in Madagascar no data exist concerning this nasal carriage of S. aureus.

Methodology: Nasal swabs from 304 different patients attending the Laboratory of Training and Research in Medical Biology of Madagascar were cultured for methicillin sensitive (MSSA) and MRSA.

Results: One hundred and sixteen patients had S. aureus in their noses (38.16 ± 5.46%) of whom 45 (14.80 ± 3.99%) had MRSA.  A risk factor for MSSA nasal carriage included a history of hospitalization when antibiotics were administered (odds ratio [OR] 2.25, 1.09 - 4.64). Among MRSA nasal isolates, high rate of resistance to other antibiotics was observed, particularly for trimethoprim-sulfamethoxazole (68.89%), erythromycin (66.67%) and ofloxacin (53.33%).

Conclusion: Our data showed a high rate of MRSA nasal carriage and a high rate of multidrug resistance. A strategic policy against the spread of multidrug resistant strains is desirable.

Author Biographies

Tsiry Rasamiravaka, Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

Faculty of Medecine of Antananarivo, M.D

Saida Rasoanandrasana, Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

Faculty of Medecine of Antananarivo, M.D

Norosoa Julie Julie Zafindraibe, Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

Faculty of Medecine of Antananarivo, M.D

Aimee Olivat Rakoto Alson, Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

Faculty of Medecine of Antananarivo, M.D Professor Chief of Department of medical biology

Andry Rasamindrakotroka, Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar

Faculty of Medecine of Antananarivo M.D,Professor

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Published

2013-04-17

How to Cite

1.
Rasamiravaka T, Rasoanandrasana S, Zafindraibe NJJ, Rakoto Alson AO, Rasamindrakotroka A (2013) Evaluation of methicillin-resistant Staphylococcus aureus nasal carriage in Malagasy patients. J Infect Dev Ctries 7:318–322. doi: 10.3855/jidc.2460

Issue

Vol. 7 No. 04: April 2013

Section

Original Articles

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