First molecular-based detection of mucocutaneous leishmaniasis caused by Leishmania major in Iran

  • Abdolvahab Alborzi Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Gholam R Pouladfar Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Abdolkarim Ghadimi Moghadam Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Armin Attar Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Nima Drakhshan Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mohsen Khosravi Maharlooei Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mohsen Kalantari Mamasani Paramedical School, Shiraz University of Medical Sciences, Shiraz, Iran
Keywords: mucocutaneous leishmaniasis, Leishmania major, PCR, Iran

Abstract

Mucocutaneous leishmaniasis, which mostly occurs in the New World, is mainly associated with Leishmania braziliensis and to a lesser degree L. panamensis and L. amazonensis infections. Primary mucosal leishmaniasis is very rare in Iran in spite of high prevalence of cutaneous and visceral leishmanisis. A nine-year-old boy had cutaneous leishmaniaisis for five years involving the left side of his face; he then developed swelling and ulceration of the lip and left side buccal mucosa five months before hospital admission. He had severe swelling of the lower lip and there was ulceration and bleeding of the buccal mucosa. Direct smear revealed leishman bodies and nested PCR confirmed the presence of kinetoplast DNA of L. major in the oral mucosal specimen. The patient received amphotericin B deoxycholate 1 mg/kg/day for one month. The lip and face inflammatory reaction disappeared to nearly normal after one month of therapy. The patient was discharged with ketoconazole (5mg/kg/day) for six weeks. To our knowledge, this is the first report of mucocutaneous leishmaniasis caused by L. major in Iran.

Author Biographies

Abdolvahab Alborzi, Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Professor in

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences

Gholam R Pouladfar, Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

MD in

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences

Abdolkarim Ghadimi Moghadam, Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

MD in

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences

Armin Attar, Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

MD in

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences

Nima Drakhshan, Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

MD in

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences

Mohsen Khosravi Maharlooei, Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

MD in

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences

Mohsen Kalantari, Mamasani Paramedical School, Shiraz University of Medical Sciences, Shiraz, Iran

Instructor

Mamasani Paramedical School, Shiraz University of Medical Sciences, Shiraz, Iran

Published
2013-05-13
How to Cite
1.
Alborzi A, Pouladfar GR, Ghadimi Moghadam A, Attar A, Drakhshan N, Khosravi Maharlooei M, Kalantari M (2013) First molecular-based detection of mucocutaneous leishmaniasis caused by Leishmania major in Iran. J Infect Dev Ctries 7:413-416. doi: 10.3855/jidc.2754
Section
Case Reports