Community-acquired CTX-M-15-type ESBL-producing Escherichia coli meningitis: a case report and literature review

  • Nazif Elaldi Cumhuriyet University, Sivas, Turkey
  • Mustafa Gokhan Gozel Cumhuriyet University, Sivas, Turkey
  • Fetiye Kolayli Kocaeli University, Izmit, Turkey
  • Aynur Engin Cumhuriyet University, Sivas, Turkey
  • Cem Celik Cumhuriyet University, Sivas, Turkey
  • Mustafa Zahir Bakici Cumhuriyet University, Sivas, Turkey
  • Haluk Vahaboglu Kocaeli University, Izmit, Turkey
Keywords: Escherichia coli, CTX-M-15, meningitis

Abstract

In this report, a case of community-acquired acute bacterial meningitis (CA-ABM) caused by CTX-M-15-producing Escherichia coli in an elderly male patient was presented in the light of literature. Cultures of cerebrospinal fluid, blood, ear discharge, and stool samples yielded CTX-M-15-producing E. coli in-vitro, which was resistant to the extended-spectrum cephalosporins and ciprofloxacin and susceptible to imipenem, meropenem and amikacin. Meningitis was treated with parenteral meropenem plus parenteral and intraventricular amikacin administration. Since bacterial meningitis is a life-threatening infection, empiric antibiotic therapy with carbapenem can be started before the culture results are obtained, mainly in areas where the ESBL epidemiology is well known.

Author Biographies

Nazif Elaldi, Cumhuriyet University, Sivas, Turkey

Professor, MD, Head of Department

Department of Infectious Diseases and Clinical Bacteriology

Mustafa Gokhan Gozel, Cumhuriyet University, Sivas, Turkey

Assistant Professor, MD

Department of Infectious Diseases and Clinical Bacteriology

Fetiye Kolayli, Kocaeli University, Izmit, Turkey

Professsor, PhD

Department of Clinical Microbiology

Aynur Engin, Cumhuriyet University, Sivas, Turkey

Associate Professor, MD

Department of Infectious Diseases and Clinical Bacteriology

Cem Celik, Cumhuriyet University, Sivas, Turkey

Assistant Professor, PhD

Department of Clinical Microbiology

Mustafa Zahir Bakici, Cumhuriyet University, Sivas, Turkey

Professor, PhD,

Department of Clinical Microbiology

Haluk Vahaboglu, Kocaeli University, Izmit, Turkey

Professor, MD

Department of Infectious Diseases and Clinical Bacteriology

Published
2013-05-13
How to Cite
1.
Elaldi N, Gozel MG, Kolayli F, Engin A, Celik C, Bakici MZ, Vahaboglu H (2013) Community-acquired CTX-M-15-type ESBL-producing Escherichia coli meningitis: a case report and literature review. J Infect Dev Ctries 7:424-431. doi: 10.3855/jidc.2820
Section
Case Reports