Sodium chloride 0.9% versus Lactated Ringer in the management of severely dehydrated patients with choleriform diarrhoea

Authors

  • Javier Antonio Cieza Nephrology Service, University Hospital, Cayetano Heredia Peruvian University, Lima, Perú
  • Juana Hinostroza Nephrology Service, Renal Heath National Center, Lima, Perú
  • Julio Arturo Huapaya Scientific Society of Medical Students, Cayetano Heredia Peruvian University, Lima, Perú
  • Cristian Paul León Nephrology Service, University Hospital, Cayetano Heredia Peruvian University, Lima, Perú

DOI:

https://doi.org/10.3855/jidc.2531

Keywords:

cholera, diarrhoea, isotonic solutions, Lactated Ringer’s solution, rehydration, sodium chloride 0.9%

Abstract

Introduction: Although experience within Peru suggests clinical and physiological benefits of treating dehydration caused by diarrhoea with Lactated Ringer’s solution (LR) over sodium chloride 0.9%, (NaCl) there is little documented scientific evidence supporting this view. It is important to clarify this issue and determine the best solution for use during epidemics.

Methodology: Forty patients suffering from dehydration due to choleriform diarrhoea were enrolled in the study. Twenty patients were treated using NaCl (Group A) and the other twenty with LR (Group B). After diuresis recovery was achieved, the patients were continued on a course of oral rehydration salts. Serum electrolytes, arterial pH, HCO3-, and pCO2 were measured at three stages: at admission, after diuresis recovery, and after 12 hours.

Results: Acidosis was corrected more quickly with LR that NaCl. The hyperosmolality and hypernatremic states were corrected with both solutions.

Conclusion: LR use resulted in a better clinical response than NaCl, illustrated by more rapid physiological correction, showing that mixed metabolic acidosis was corrected more quickly and more appropriately with this treatment.

Author Biographies

Javier Antonio Cieza, Nephrology Service, University Hospital, Cayetano Heredia Peruvian University, Lima, Perú

Chief of Nephrology Service, University Hospital, Cayetano Heredia Peruvian University

Julio Arturo Huapaya, Scientific Society of Medical Students, Cayetano Heredia Peruvian University, Lima, Perú

Past President of Scientific Society of Medical Student, Cayetano Heredia Peruvian University.

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Published

2013-07-15

How to Cite

1.
Cieza JA, Hinostroza J, Huapaya JA, León CP (2013) Sodium chloride 0.9% versus Lactated Ringer in the management of severely dehydrated patients with choleriform diarrhoea. J Infect Dev Ctries 7:528–532. doi: 10.3855/jidc.2531

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Section

Original Articles