Enteric fever burden in North Jakarta, Indonesia: a prospective, community-based study

Narain H Punjabi; Magdarina D Agtini; R. Leon Ochiai; Cyrus H Simanjuntak; Murad Lesmana; Decy Subekti; Buhari A Oyofo; Lorenz von Seidlein; Jacqueline Deen; Seonghye Shin; Camilo Acosta; Ferry Wangsasaputra; Sri P Pulungsih; Santoso Saroso; Suyeti Suyeti; Suharno R; Pratiwi Sudarmono; Agus Syarurachman; Agus Suwandono; Sumarjati Arjoso; H. James Beecham III; Andrew L Corwin; John D Clemens

doi:10.3855/jidc.2629

Enteric fever burden in North Jakarta, Indonesia: a prospective, community-based study

Authors

Narain H Punjabi U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
Magdarina D Agtini National Institute of Health Research and Development R.I, Jakarta, Indonesia
R. Leon Ochiai International Vaccine Institute, Seoul, Korea
Cyrus H Simanjuntak U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
Murad Lesmana U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
Decy Subekti U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
Buhari A Oyofo U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
Lorenz von Seidlein International Vaccine Institute, Seoul, Korea
Jacqueline Deen International Vaccine Institute, Seoul, Korea
Seonghye Shin International Vaccine Institute, Seoul, Korea
Camilo Acosta International Vaccine Institute, Seoul, Korea
Ferry Wangsasaputra National Institute of Health Research and Development R.I, Jakarta, Indonesia
Sri P Pulungsih Infectious Diseases Hospital Prof. Dr. Sulianti Saroso, Jakarta, Indonesia
Santoso Saroso Infectious Diseases Hospital Prof. Dr. Sulianti Saroso, Jakarta, Indonesia
Suyeti Suyeti International Vaccine Institute, Seoul, Korea
Suharno R National Institute of Health Research and Development R.I, Jakarta, Indonesia
Pratiwi Sudarmono Microbiology Department, University of Indonesia, Jakarta, Indonesia
Agus Syarurachman Microbiology Department, University of Indonesia, Jakarta, Indonesia
Agus Suwandono National Institute of Health Research and Development R.I, Jakarta, Indonesia
Sumarjati Arjoso National Institute of Health Research and Development R.I, Jakarta, Indonesia
H. James Beecham III U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
Andrew L Corwin U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
John D Clemens International Vaccine Institute, Seoul, Korea

DOI:

https://doi.org/10.3855/jidc.2629

Keywords:

enteric fever, typhoid fever, paratyphoid fever, incidence

Abstract

Introduction: We undertook a prospective community-based study in North Jakarta, Indonesia, to determine the incidence, clinical characteristics, seasonality, etiologic agent, and antimicrobial susceptibility pattern of enteric fever.

Methodology: Following a census, treatment centre-based surveillance for febrile illness was conducted for two-years. Clinical data and a blood culture were obtained from each patient.

Results: In a population of 160,261, we detected 296 laboratory-confirmed enteric fever cases during the surveillance period, of which 221 (75%) were typhoid fever and 75 (25%) were paratyphoid fever. The overall incidence of typhoid and paratyphoid cases was 1.4, and 0.5 per thousand populations per year, respectively. Although the incidence of febrile episodes evaluated was highest among children under 5 years of age at 92.6 per thousand persons per year, we found that the burden of typhoid fever was greatest among children between 5 and 20 years of age. Paratyphoid fever occurred most commonly in children and was infrequent in adults.

Conclusion: Enteric fever is a public health problem in North Jakarta with a substantial proportion due to paratyphoid fever. The results highlight the need for control strategies against enteric fever.

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Published

2013-11-15

How to Cite

Punjabi NH, Agtini MD, Ochiai RL, Simanjuntak CH, Lesmana M, Subekti D, Oyofo BA, von Seidlein L, Deen J, Shin S, Acosta C, Wangsasaputra F, Pulungsih SP, Saroso S, Suyeti S, R S, Sudarmono P, Syarurachman A, Suwandono A, Arjoso S, Beecham III HJ, Corwin AL, Clemens JD (2013) Enteric fever burden in North Jakarta, Indonesia: a prospective, community-based study. J Infect Dev Ctries 7:781–787. doi: 10.3855/jidc.2629

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Issue

Vol. 7 No. 11: November 2013

Section

Original Articles

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