Interleukin-8 is elevated in severe hand, foot, and mouth disease

  • Wen Wang Beijing You’an Hospital, Capital Medical University, Beijing, China
  • Wei Li Beijing You’an Hospital, Capital Medical University, Beijing, China
  • Xue Yang Beijing You’an Hospital, Capital Medical University, Beijing, China
  • Tong Zhang Beijing You’an Hospital, Capital Medical University, Beijing, China
  • Yuxuan Wang State University of New York at Binghamton, Binghamton, New York, United States
  • Rui Zhong Beijing You’an Hospital, Capital Medical University, Beijing, China
  • Yanmei Jiao Beijing You’an Hospital, Capital Medical University, Beijing, China
  • Tongzeng Li Beijing You’an Hospital, Capital Medical University, Beijing, China
  • Taiyi Jiang Beijing You’an Hospital, Capital Medical University, Beijing, China
  • Yakun Tian Beijing You’an Hospital, Capital Medical University, Beijing, China
  • Hao Wu Beijing You’an Hospital, Capital Medical University, Beijing, China
Keywords: interleukin-8, cytokine, hand, foot, and mouth disease, serum marker, disease severity

Abstract

Introduction: Enterovirus 71 (EV71) infections can cause hand, foot, and mouth disease (HFMD), which is a potentially fatal illness in children. Epidemics of HFMD are seen every year globally and present an increasing threat to public health worldwide.

Methodology: To identify potential severity markers for severe HFMD, laboratory findings and levels of eight serum cytokines in 143 EV71-infected patients in Beijing You’an Hospital were analyzed. Patients were grouped by disease severity: Mild (no severe complications) (n = 59), isolated isolated brainstem encephalitis (BE) (n = 47), isolated pulmonary edema (PE) (n = 12), and BE+PE (n = 25).

Results: IL-8 levels peaked at day one after admission and were found to be correlated to disease severity, maximal body temperature, and length of hospital stay. Among all tested cytokines, IL-8 was correlated to only IL-6 (p = 0.010). IL-6 and IL-10 were elevated in most patients (98.6% and 70.6%), but not correlated to disease severity (both p > 0.05). IFNg was only negatively correlated to mild cases (p = 0.025).

Conclusions: IL-8 was correlated to disease severity of HFMD. IL-6 and IL-10, although elevated in most HFMD patients, were not correlated to disease severity.

Published
2014-01-15
How to Cite
1.
Wang W, Li W, Yang X, Zhang T, Wang Y, Zhong R, Jiao Y, Li T, Jiang T, Tian Y, Wu H (2014) Interleukin-8 is elevated in severe hand, foot, and mouth disease. J Infect Dev Ctries 8:094-100. doi: 10.3855/jidc.3542
Section
Original Articles