Are bone morphogenetic protein-7 (BMP-7) serum levels correlated with development of hepatic fibrosis?

  • Nazlim Aktug Demir Selcuk University, Faculty of Medicine, Konya, Turkey
  • Servet Kolgelier Adiyaman University, Faculty of Medicine, Adiyaman, Turkey
  • Ahmet Cagkan Inkaya Hacettepe University, Faculty of Medicine, Ankara, Turkey
  • Sua Sumer Selcuk University, Faculty of Medicine, Konya, Turkey
  • Lutfi Saltuk Demir Necmettin Erbakan University,Meram Faculty of Medicine, Konya, Turkey
  • Fatma Seher Pehlivan Adiyaman State Hospital, Adiyaman, Turkey
  • Mahmure Arslan Adiyaman State Hospital, Adiyaman, Turkey
  • Abdullah Arpaci Adiyaman State Hospital, Adiyaman, Turkey
Keywords: BMP-7, chronic hepatitis B, fibrosis

Abstract

Introduction: Bone morphogenetic protein-7 (BMP-7) is a key protein in organogenesis and liver development. The protein has been studied in the context of liver fibrosis and regeneration. The aim of the present study was to explore any possible association between fibrosis levels (as revealed by liver biopsy) and serum BMP-7 levels.

Methodology: A total of 189 patients with chronic hepatitis B and 51 healthy controls were enrolled in the study.

Results: The study group contained 120 (63.5%) males and 69 (36.5%) females, and the control group contained 25 males (49.0%) and 26 females (51%). In general, serum BMP-7 values of patients were higher than those of controls (p = 0.001). Serum BMP-7 values of patients with liver fibrosis of stages 1, 2, 3, or 4 were higher than control values (all p values = 0.01), but the serum BMP-7 levels of patients with stage 5 fibrosis were similar to that of controls. Associations between fibrosis stage and the serum levels of BMP-7, ALT, HBVDNA, platelets, and albumin were all statistically significant (p = 0.001). The AUROC for the BMP-7 level in advanced stage fibrosis was found to be 0.23. The data were analyzed using the binary logistic regression analysis (backward stepwise method) and BMP-7, HBVDNA, and platelet levels were found to be risk factors associated with fibrosis (p values 0.031, 0.040, and 0.001, respectively).

Conclusions: BMP-7 may play anti-inflammatory and anti-fibrogenic roles in the pathogenesis of chronic hepatitis B infection.

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Author Biographies

Nazlim Aktug Demir, Selcuk University, Faculty of Medicine, Konya, Turkey

Asistant Professor in Infectious Disease and Clinical Microbiology

Department of Infectious Disease and Clinical Microbiology

Servet Kolgelier, Adiyaman University, Faculty of Medicine, Adiyaman, Turkey

Asistant Professor in Infectious Disease and Clinical Microbiology

Department of Infectious Disease and Clinical Microbiology

Ahmet Cagkan Inkaya, Hacettepe University, Faculty of Medicine, Ankara, Turkey

Medical Doctor in Infectious Disease

Departmentof Internal Medicine, Division of Infectious Diseases

Sua Sumer, Selcuk University, Faculty of Medicine, Konya, Turkey

Asistant Professor in Infectious Disease and Clinical Microbiology

Department of Infectious Disease and Clinical Microbiology

Lutfi Saltuk Demir, Necmettin Erbakan University,Meram Faculty of Medicine, Konya, Turkey
Medical Doctor in Public Health Management
Fatma Seher Pehlivan, Adiyaman State Hospital, Adiyaman, Turkey

Medical Doctor in Pathology

Departmentof Pathology

Mahmure Arslan, Adiyaman State Hospital, Adiyaman, Turkey

Medical Doctor in Biochemistry

Departmentof Biochemistry

Abdullah Arpaci, Adiyaman State Hospital, Adiyaman, Turkey
Professor in Biochemistry

Departmentof Biochemistry

Published
2014-05-14
How to Cite
1.
Aktug DemirN, Kolgelier S, Inkaya AC, Sumer S, Demir LS, Pehlivan FS, Arslan M, Arpaci A (2014) Are bone morphogenetic protein-7 (BMP-7) serum levels correlated with development of hepatic fibrosis?. J Infect Dev Ctries 8:605-610. doi: 10.3855/jidc.4033
Section
Original Articles