An eight-year study of Shigella species in Beijing, China: serodiversity, virulence genes, and antimicrobial resistance

Authors

  • Mei Qu Beijing Centre for Disease Prevention and Control, Beijing, China
  • Xin Zhang Beijing Centre for Disease Prevention and Control, Beijing, China
  • Guirong Liu Beijing Centre for Disease Prevention and Control, Beijing, China
  • Ying Huang Beijing Centre for Disease Prevention and Control, Beijing, China
  • Lei Jia Beijing Centre for Disease Prevention and Control, Beijing, China
  • Weili Liang National Institute for Communicable Disease Control and Prevention, Beijing, China
  • Xitai Li Beijing Centre for Disease Prevention and Control, Beijing, China
  • Xiaona Wu Beijing Centre for Disease Prevention and Control, Beijing, China
  • Jie Li Beijing Centre for Disease Prevention and Control, Beijing, China
  • Hanqiu Yan Beijing Centre for Disease Prevention and Control, Beijing, China
  • Biao Kan National Institute for Communicable Disease Control and Prevention, Beijing, China
  • Quanyi Wang Beijing Centre for Disease Prevention and Control, Beijing, China

DOI:

https://doi.org/10.3855/jidc.3692

Keywords:

Shigella, serodiversity, prevalence, antimicrobial resistance, diarrhea

Abstract

Introduction: This study was conducted to determine the prevalence of serotypes, virulence factors, and antimicrobial resistance patterns of Shigella spp. in Beijing, China, from 2004 to 2011.

Methodology: Real-time PCR assays were used to detect virulent genes, and the Kirby-Bauer disk diffusion method was used to evaluate antimicrobial resistance.

Results: Among the total of 1,652 Shigella isolates, S. sonnei (57.1%) was the predominant species, followed by S. flexneri (42.3%), S. dysenteriae (0.4%), and S. boydii (0.2%). Nineteen serotypes were discovered among S. flexneri strains. The virulence gene ipaH was the most frequent, followed by sen and set. The presence of set showed significant difference in two dominant serogroups, S. flexneri and S. sonnei. Over 90% of Shigella isolates showed resistance to at least three drugs with widened spectrum. High-level antimicrobial resistance to single and multiple antibiotics was more common among S. sonnei than S. flexneri.

Conclusion: There was an obvious serotype change and a dramatic increase of antibiotic resistance in Shigella prevalence in Beijing.

Author Biography

Mei Qu, Beijing Centre for Disease Prevention and Control, Beijing, China

Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning,

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Published

2014-07-14

How to Cite

1.
Qu M, Zhang X, Liu G, Huang Y, Jia L, Liang W, Li X, Wu X, Li J, Yan H, Kan B, Wang Q (2014) An eight-year study of Shigella species in Beijing, China: serodiversity, virulence genes, and antimicrobial resistance. J Infect Dev Ctries 8:904–908. doi: 10.3855/jidc.3692

Issue

Vol. 8 No. 07: July 2014

Section

Brief Original Articles

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