A case of human infection with avian Influenza A/H7N9 virus in Beijing: virological and serological analysis

  • Yang Pan Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
  • Weixian Shi Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
  • Peng Yang Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
  • Shuangsheng Wu Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
  • Xiaomin Peng Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
  • Shujuan Cui Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
  • Daitao Zhang Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
  • Guilan Lu Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
  • Jiachen Zhao Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
  • Yimeng Liu Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
  • Quanyi Wang Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Keywords: Influenza, H7N9 avian influenza, drug resistance, antibody, viral load

Abstract

This study described some essential viral and sera-characteristics of A/H7N9 virus infection in a 61-year old case patient. With the antiviral therapy and respiratory support, the patient showed a significant decrease of viral loads from 6.72 log10 copies/mL to 0 in 22 days, and a correlated increase of serum hemagglutination inhibition titers during the same period. Phylogenetic analysis demonstrated that the isolated strain was highly homologous to previous strains isolated in the southeast of China. Drug resistance-associated R292K mutation became detectable 17 days after antiviral therapy, but no remarkable influence on the viral clearance was observed.

Published
2015-03-15
How to Cite
1.
Pan Y, Shi W, Yang P, Wu S, Peng X, Cui S, Zhang D, Lu G, Zhao J, Liu Y, Wang Q (2015) A case of human infection with avian Influenza A/H7N9 virus in Beijing: virological and serological analysis. J Infect Dev Ctries 9:317-320. doi: 10.3855/jidc.5875
Section
Case Reports