A case of human infection with avian Influenza A/H7N9 virus in Beijing: virological and serological analysis

Yang Pan; Weixian Shi; Peng Yang; Shuangsheng Wu; Xiaomin Peng; Shujuan Cui; Daitao Zhang; Guilan Lu; Jiachen Zhao; Yimeng Liu; Quanyi Wang

doi:10.3855/jidc.5875

A case of human infection with avian Influenza A/H7N9 virus in Beijing: virological and serological analysis

Authors

Yang Pan Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Weixian Shi Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Peng Yang Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Shuangsheng Wu Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Xiaomin Peng Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Shujuan Cui Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Daitao Zhang Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Guilan Lu Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Jiachen Zhao Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Yimeng Liu Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China
Quanyi Wang Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China

DOI:

https://doi.org/10.3855/jidc.5875

Keywords:

Influenza, H7N9 avian influenza, drug resistance, antibody, viral load

Abstract

This study described some essential viral and sera-characteristics of A/H7N9 virus infection in a 61-year old case patient. With the antiviral therapy and respiratory support, the patient showed a significant decrease of viral loads from 6.72 log₁₀ copies/mL to 0 in 22 days, and a correlated increase of serum hemagglutination inhibition titers during the same period. Phylogenetic analysis demonstrated that the isolated strain was highly homologous to previous strains isolated in the southeast of China. Drug resistance-associated R292K mutation became detectable 17 days after antiviral therapy, but no remarkable influence on the viral clearance was observed.

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Published

2015-03-15

How to Cite

Pan Y, Shi W, Yang P, Wu S, Peng X, Cui S, Zhang D, Lu G, Zhao J, Liu Y, Wang Q (2015) A case of human infection with avian Influenza A/H7N9 virus in Beijing: virological and serological analysis. J Infect Dev Ctries 9:317–320. doi: 10.3855/jidc.5875

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Issue

Vol. 9 No. 03: March 2015

Section

Case Reports

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