Seroprevalence of hepatitis B surface antigen and hepatitis B e antigen among childbearing-age women in Mianyang, China

  • Min Wang West China School of Public Health, Sichuan University, Chengdu, Sichuan, China
  • Hong Li West China Hospital, Sichuan University, Chengdu, Sichuan, China
  • Yulin Ji West China Hospital, Sichuan University, Chengdu, Sichuan, China
  • Yuanji Ma West China Hospital, Sichuan University, Chengdu, Sichuan, China
  • Liping Wang Jiangyou County Center for Disease Control and Prevention, Mianyang, Sichuan, China
  • Tao Ren Fucheng District Center for Disease Control and Prevention, Mianyang, Sichuan, China
  • Fengsu Hou West China School of Public Health, Sichuan University, Chengdu, Sichuan, China
  • Ping Yuan West China School of Public Health, Sichuan University, Chengdu, Sichuan, China
Keywords: childbearing-age women, hepatitis B surface antigen, hepatitis B e antigen, seroprevalence, China

Abstract

Introduction: Few studies have focused on hepatitis B virus (HBV) infection among childbearing-age women. This study explored hepatitis B surface antigen (HBsAg) seroprevalence and hepatitis B e antigen (HBeAg) seroprevalence and their associated factors among childbearing-age women.

Methodology: A cross-sectional, population-based study was conducted between June 2013 and October 2013 in Mianyang; women 15–49 years of age were enrolled using a multistage cluster sampling design. Participants completed questionnaires about demographic characteristics and potential factors associated with HBV infection, and provided blood samples for screening HBsAg and HBeAg. The analysis methods included descriptive statistics, Chi-square test, and multivariate logistic regression.

Results: Among 62,007 childbearing-age women, 5.66% were HBsAg positive. The HBsAg seroprevalence rates were 7.28% in women 40–44 years of age, 7.0% in Fucheng women, 5.70% in Han women, 6.59% in married women, and 6.60% in agriculture workers. Multivariate models identified having HBsAg-positive family members, and having no self-reported immunization history to be positively associated with HBsAg positivity; being a healthcare worker was negatively associated with HBsAg positivity. Among 3,499 HBsAg-positive childbearing-age women, 9.97% were HBeAg positive. The HBeAg seroprevalence rates were 46.54% in women 15–19 years of age, 10.82% in Fucheng women, 38.51% in single women, and 42.86% in students. Multivariate models identified living in Fucheng and younger age to be positively associated with HBeAg positivity.

Conclusions: These findings could provide scientific evidence for the Chinese government to plan efficient health care services and prevention initiatives, and to allocate health resources reasonably for this population.

Author Biographies

Min Wang, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China

Department of Epidemiology and Statistics, West China School of Public Health

Hong Li, West China Hospital, Sichuan University, Chengdu, Sichuan, China

Department of Urology, West China Hospital

Yulin Ji, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Department of Respiratory Medicine, West China Hospital
Yuanji Ma, West China Hospital, Sichuan University, Chengdu, Sichuan, China

Department of Infectious Disease, West China Hospital

Fengsu Hou, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China
Department of Epidemiology and Statistics, West China School of Public Health
Ping Yuan, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China

Department of Epidemiology and Statistics, West China School of Public Health

Published
2015-07-30
How to Cite
1.
Wang M, Li H, Ji Y, Ma Y, Wang L, Ren T, Hou F, Yuan P (2015) Seroprevalence of hepatitis B surface antigen and hepatitis B e antigen among childbearing-age women in Mianyang, China. J Infect Dev Ctries 9:770-779. doi: 10.3855/jidc.6938
Section
Original Articles