Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia

Xilian Huang; Yaping Xie; Daquan Gao; Pengfei Shi; Shenxian Qian

doi:10.3855/jidc.5084

Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia

Authors

Xilian Huang Hangzhou First People’s Hospital, Hangzhou, China
Yaping Xie Hangzhou First People’s Hospital, Hangzhou, China
Daquan Gao Hangzhou First People’s Hospital, Hangzhou, China
Pengfei Shi Hangzhou First People’s Hospital, Hangzhou, China
Shenxian Qian Hangzhou First People’s Hospital, Hangzhou, China

DOI:

https://doi.org/10.3855/jidc.5084

Keywords:

hepatitis C, thrombocytopenic, splenectomy

Abstract

This case report describes a 44-year-old female with hepatitis C virus-related thrombocytopenia. The laboratory tests showed a platelet count of 3×10⁹/l, positive HCV serology and high serum concentration of HCV-RNA of 6.74×10⁶ copy/ml. She was refractory to standard therapies including corticosteroids, intravenous immunoglobulin (IVIG), thrombopoietin (TPO) and even interferon (IFN) regimens, due to the persistence of a low platelet count. At first, splenectomy was thought to be impossible, but then splenectomy was successfully performed and patient showed good tolerance and a constant normal platelet count after surgery. In conclusion, splenectomy is feasible in selected patients and may allow us to acquire a reasonable platelet count and completion of an anti-HCV protocol. Low platelet count itself should not be the contraindication of operation specifically for these patients. Further studies in larger numbers of patients and over a longer period of time are warranted.

Author Biographies

Xilian Huang, Hangzhou First People’s Hospital, Hangzhou, China

specialty:thrombosis and hemostasis

Shenxian Qian, Hangzhou First People’s Hospital, Hangzhou, China

Head of Department of Hematology,Hangzhou First People’s Hospital

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Published

2015-07-30

How to Cite

Huang X, Xie Y, Gao D, Shi P, Qian S (2015) Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia. J Infect Dev Ctries 9:785–787. doi: 10.3855/jidc.5084

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Issue

Vol. 9 No. 07: July 2015

Section

Case Reports

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