Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia

  • Xilian Huang Hangzhou First People’s Hospital, Hangzhou, China
  • Yaping Xie Hangzhou First People’s Hospital, Hangzhou, China
  • Daquan Gao Hangzhou First People’s Hospital, Hangzhou, China
  • Pengfei Shi Hangzhou First People’s Hospital, Hangzhou, China
  • Shenxian Qian Hangzhou First People’s Hospital, Hangzhou, China
Keywords: hepatitis C, thrombocytopenic, splenectomy

Abstract

This case report describes a 44-year-old female with hepatitis C virus-related thrombocytopenia. The laboratory tests showed a platelet count of 3×109/l, positive HCV serology and high serum concentration of HCV-RNA of 6.74×106 copy/ml. She was refractory to standard therapies including corticosteroids, intravenous immunoglobulin (IVIG), thrombopoietin (TPO) and even interferon (IFN) regimens, due to the persistence of a low platelet count. At first, splenectomy was thought to be impossible, but then splenectomy was successfully performed and patient showed good tolerance and a constant normal platelet count after surgery. In conclusion, splenectomy is feasible in selected patients and may allow us to acquire a reasonable platelet count and completion of an anti-HCV protocol. Low platelet count itself should not be the contraindication of operation specifically for these patients. Further studies in larger numbers of patients and over a longer period of time are warranted.

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Author Biographies

Xilian Huang, Hangzhou First People’s Hospital, Hangzhou, China
specialty:thrombosis and hemostasis
Shenxian Qian, Hangzhou First People’s Hospital, Hangzhou, China

Head of Department of Hematology,Hangzhou First People’s Hospital

Published
2015-07-30
How to Cite
1.
Huang X, Xie Y, Gao D, Shi P, Qian S (2015) Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia. J Infect Dev Ctries 9:785-787. doi: 10.3855/jidc.5084
Section
Case Reports