Comparison between potential risk factors for cardiovascular disease in people living with HIV/AIDS in areas of Brazil

  • Ricardo AA Ximenes Universidade de Pernambuco, Recife, Brazil
  • Heloisa R Lacerda Universidade Federal de Pernambuco, Recife, Brazil
  • Democrito B Miranda-Filho Universidade de Pernambuco, Recife, Brazil
  • Maria de Fatima PM Albuquerque Fundação Oswaldo Cruz, Recife, Brazil
  • Ulisses R Montarroyos Universidade de Pernambuco, PE, Brazil
  • Marilia D Turchi Universidade Federal de Goiás, Goiania, Brazil
  • Max W Nery Universidade Federal de Goiás, Goiania, Brazil
  • Celina MT Martelli Universidade Federal de Goiás, Goiania, Brazil
  • Paulo R Alencastro Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
  • Maria Leticia R Ikeda School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
  • Fernando H Wolff Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
  • Ajacio BM Brandao Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
  • Nemora T Barcellos Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
  • Sandra C Fuchs School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Keywords: HIV, coronary heart disease, prevalence, Brazil

Abstract

Introduction: Coronary heart disease and its risk factors depend on genetic characteristics, behaviors, and habits, all of which vary in different regions. The use of antiretroviral therapy (ARV) has increased the survival of people living with HIV/AIDS (PLWHA), who begin to present mortality indicators similar to the general population. This study aimed to compare the prevalence of factors potentially associated with coronary heart disease in three cohorts of PLWHA from three different regions of Brazil.

Methodology: The study population was composed of participants of the cohorts of Pernambuco, Goiás, and Rio Grande do Sul states. In these sites, adult patients attending reference centers for treatment of HIV/AIDS were consecutively enrolled.

Results: Pernambuco and Goiás had a higher proportion of males and of individuals with high-risk high-density lipoprotein (HDL). Pernambuco also had a greater proportion of individuals with hypertension, elevated triglycerides, and CD4 counts below 200 cells/mm3. Lower education was more frequent in Rio Grande do Sul, and the use of cocaine was higher in this state.

Conclusions: The results confirm the importance of risk factors for coronary heart disease in PLHIV and highlight differences in the three cohorts. Specific measures against smoking and sedentary lifestyle, avoidance of advanced stages of immunosuppression, and appropriate treatment of dyslipidemia and dysglicemia are urgently needed to cope with the disease in Brazil.

Author Biographies

Ricardo AA Ximenes, Universidade de Pernambuco, Recife, Brazil

Reader in Infectious Diseases Epidemiology

Departamento de Medicina Tropical, Universidade Federal de Pernambuco, PE, Brasil.

and

Departamento de Clinica Medica, Universidade de Pernambuco, PE, Brasil

Heloisa R Lacerda, Universidade Federal de Pernambuco, Recife, Brazil

Reader in Infectious Diseases

Departamento de Medicina Tropical

Democrito B Miranda-Filho, Universidade de Pernambuco, Recife, Brazil

Reader in Infectious Diseases

Departamento de Clínica Médica

Maria de Fatima PM Albuquerque, Fundação Oswaldo Cruz, Recife, Brazil

Senior Researcher

Departamento de Saude Publica

Centro de Pesquisa Aggeu Magalhães

Ulisses R Montarroyos, Universidade de Pernambuco, PE, Brazil

Reader in Biostatistics

Instituto de Ciências Biológicas

Marilia D Turchi, Universidade Federal de Goiás, Goiania, Brazil

Professor in Infectious Diseases

Instituto de Patologia Tropical e Saúde Pública

Max W Nery, Universidade Federal de Goiás, Goiania, Brazil
Instituto de Patologia Tropical e Saúde Públical
Celina MT Martelli, Universidade Federal de Goiás, Goiania, Brazil

Professor in Infectious Diseases Epidemiology

Instituto de Patologia Tropical e Saúde Pública

Paulo R Alencastro, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
National Institute for Health Technology Assessment (IATS/CNPq)
Maria Leticia R Ikeda, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Postgraduate Studies Program in Epidemiology, School of Medicine,
Fernando H Wolff, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

National Institute for Health Technology Assessment (IATS/CNPq), Hospital de Clínicas de Porto Alegre, RS, Brazil.

 

Ajacio BM Brandao, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

National Institute for Health Technology Assessment (IATS/CNPq), Hospital de Clínicas de Porto Alegre, RS, Brazil.

 

Nemora T Barcellos, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

National Institute for Health Technology Assessment (IATS/CNPq), Hospital de Clínicas de Porto Alegre, RS, Brazil

Sandra C Fuchs, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

Reader

Instituto Nacional de Genética Médica Populacional, INaGeMP.

Published
2015-09-27
How to Cite
1.
Ximenes RA, Lacerda HR, Miranda-Filho DB, Albuquerque M de FP, Montarroyos UR, Turchi MD, Nery MW, Martelli CM, Alencastro PR, Ikeda MLR, Wolff FH, Brandao AB, Barcellos NT, Fuchs SC (2015) Comparison between potential risk factors for cardiovascular disease in people living with HIV/AIDS in areas of Brazil. J Infect Dev Ctries 9:988-996. doi: 10.3855/jidc.5867
Section
Original Articles