Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases

Yöntem Yaman; Salih Gözmen; Ahmet Kağan Özkaya; Yeşim Oymak; Hurşit Apa; Canan Vergin; İlker Devrim

doi:10.3855/jidc.6090

Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases

Authors

Yöntem Yaman Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Salih Gözmen Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Ahmet Kağan Özkaya Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Yeşim Oymak Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Hurşit Apa Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Canan Vergin Sütçü Imam University Medical School, Kahramanmaraş, Turkey
İlker Devrim Sütçü Imam University Medical School, Kahramanmaraş, Turkey

DOI:

https://doi.org/10.3855/jidc.6090

Keywords:

brucellosis, hemophagocytic lymphohistiocytosis, pancytopenia

Abstract

Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy. It continues to be an important health problem worldwide. Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, hepatosplenomegaly, cytopenias, high serum levels of ferritin and triglycerides, low serum fibrinogen levels, and hemophagocytosis in bone marrow, lymph nodes, spleen, or liver. Hemophagocytic lymphohistiocytosis associated with brucellosis is a very rare condition in the pediatric age group. Here, three pediatric cases of secondary HLH associated with brucellosis are reported. Hemophagocytic lymphohistiocytosis should be considered in patients with brucellosis having cytopenias. Hemophagocytosis in brucellosis seems to be cured with appropriate antibiotics and intravenous immunoglobulin.

Author Biographies

Yöntem Yaman, Sütçü Imam University Medical School, Kahramanmaraş, Turkey

Pediatric Hematologist in Department of Pediatric Hematology and Oncology

Salih Gözmen, Sütçü Imam University Medical School, Kahramanmaraş, Turkey

Pediatric Hematologist in Department of Pediatric Hematology and Oncology

Ahmet Kağan Özkaya, Sütçü Imam University Medical School, Kahramanmaraş, Turkey

Department of Pediatric Emergency

Yeşim Oymak, Sütçü Imam University Medical School, Kahramanmaraş, Turkey

Pediatric Hematologist in Department of Pediatric Hematology and Oncology

Hurşit Apa, Sütçü Imam University Medical School, Kahramanmaraş, Turkey

Associated Professor in Department of Pediatric Infectious Diseases

Canan Vergin, Sütçü Imam University Medical School, Kahramanmaraş, Turkey

Associated professor in Department of Pediatric Hematology and Oncology

İlker Devrim, Sütçü Imam University Medical School, Kahramanmaraş, Turkey

Associated professor in Department of Pediatric Infectious Diseases

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Published

2015-10-29

How to Cite

Yaman Y, Gözmen S, Özkaya AK, Oymak Y, Apa H, Vergin C, Devrim İlker (2015) Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases. J Infect Dev Ctries 9:1172–1176. doi: 10.3855/jidc.6090

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Issue

Vol. 9 No. 10: October 2015

Section

Case Reports

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