Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases

  • Yöntem Yaman Sütçü Imam University Medical School, Kahramanmaraş, Turkey
  • Salih Gözmen Sütçü Imam University Medical School, Kahramanmaraş, Turkey
  • Ahmet Kağan Özkaya Sütçü Imam University Medical School, Kahramanmaraş, Turkey
  • Yeşim Oymak Sütçü Imam University Medical School, Kahramanmaraş, Turkey
  • Hurşit Apa Sütçü Imam University Medical School, Kahramanmaraş, Turkey
  • Canan Vergin Sütçü Imam University Medical School, Kahramanmaraş, Turkey
  • İlker Devrim Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Keywords: brucellosis, hemophagocytic lymphohistiocytosis, pancytopenia

Abstract

Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy. It continues to be an important health problem worldwide. Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, hepatosplenomegaly, cytopenias, high serum levels of ferritin and triglycerides, low serum fibrinogen levels, and hemophagocytosis in bone marrow, lymph nodes, spleen, or liver. Hemophagocytic lymphohistiocytosis associated with brucellosis is a very rare condition in the pediatric age group. Here, three pediatric cases of secondary HLH associated with brucellosis are reported. Hemophagocytic lymphohistiocytosis should be considered in patients with brucellosis having cytopenias. Hemophagocytosis in brucellosis seems to be cured with appropriate antibiotics and intravenous immunoglobulin.

Author Biographies

Yöntem Yaman, Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Pediatric Hematologist in Department of Pediatric Hematology and Oncology
Salih Gözmen, Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Pediatric Hematologist in Department of Pediatric Hematology and Oncology
Ahmet Kağan Özkaya, Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Department of Pediatric Emergency
Yeşim Oymak, Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Pediatric Hematologist in Department of Pediatric Hematology and Oncology
Hurşit Apa, Sütçü Imam University Medical School, Kahramanmaraş, Turkey

Associated Professor in Department of Pediatric Infectious Diseases

Canan Vergin, Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Associated professor in Department of Pediatric Hematology and Oncology
İlker Devrim, Sütçü Imam University Medical School, Kahramanmaraş, Turkey
Associated professor in Department of Pediatric Infectious Diseases
Published
2015-10-29
How to Cite
1.
Yaman Y, Gözmen S, Özkaya A, Oymak Y, Apa H, Vergin C, Devrim İlker (2015) Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases. J Infect Dev Ctries 9:1172-1176. doi: https://doi.org/10.3855/jidc.6090
Section
Case Reports