Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: case report and systematic review of literature

  • Maria Scalzone Catholic University of Rome, Rome, Italy
  • Antonio Ruggiero Catholic University of Rome, Rome, Italy
  • Stefano Mastrangelo Catholic University of Rome, Rome, Italy
  • Giovanna Trombatore Catholic University of Rome, Rome, Italy
  • Vita Ridola Catholic University of Rome, Rome, Italy
  • Palma Maurizi Catholic University of Rome, Rome, Italy
  • Riccardo Riccardi Catholic University of Rome, Rome, Italy
Keywords: Hemophagocytic lymphohistiocytosis, leishmania, childhood, liposomal amphotericin B

Abstract

Hemophagocytic lymphohistiocytosis is a potentially fatal disorder resulting from excessive activation and non-malignant proliferation of T lymphocytes and macrophages. Neoplasms, autoimmune disorders and systemic infections can cause secondary hemophagocytic syndrome. The association of hemophagocytic syndrome and visceral leishmaniasis is rarely found in childhood.  We report a case of an infant affected by hemophagocytic lymphohistiocytosis secondary to visceral leishamniasis and describe all cases of hemophagocytic syndrome associated with visceral leishamniasis in childhood reported in literature, focusing on clinical manifestation, diagnosis and treatment.

Published
2016-01-31
How to Cite
1.
Scalzone M, Ruggiero A, Mastrangelo S, Trombatore G, Ridola V, Maurizi P, Riccardi R (2016) Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: case report and systematic review of literature. J Infect Dev Ctries 10:103-108. doi: 10.3855/jidc.6385
Section
Case Reports