Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: case report and systematic review of literature

Maria Scalzone; Antonio Ruggiero; Stefano Mastrangelo; Giovanna Trombatore; Vita Ridola; Palma Maurizi; Riccardo Riccardi

doi:10.3855/jidc.6385

Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: case report and systematic review of literature

Authors

Maria Scalzone Catholic University of Rome, Rome, Italy
Antonio Ruggiero Catholic University of Rome, Rome, Italy
Stefano Mastrangelo Catholic University of Rome, Rome, Italy
Giovanna Trombatore Catholic University of Rome, Rome, Italy
Vita Ridola Catholic University of Rome, Rome, Italy
Palma Maurizi Catholic University of Rome, Rome, Italy
Riccardo Riccardi Catholic University of Rome, Rome, Italy

DOI:

https://doi.org/10.3855/jidc.6385

Keywords:

Hemophagocytic lymphohistiocytosis, leishmania, childhood, liposomal amphotericin B

Abstract

Hemophagocytic lymphohistiocytosis is a potentially fatal disorder resulting from excessive activation and non-malignant proliferation of T lymphocytes and macrophages. Neoplasms, autoimmune disorders and systemic infections can cause secondary hemophagocytic syndrome. The association of hemophagocytic syndrome and visceral leishmaniasis is rarely found in childhood. We report a case of an infant affected by hemophagocytic lymphohistiocytosis secondary to visceral leishamniasis and describe all cases of hemophagocytic syndrome associated with visceral leishamniasis in childhood reported in literature, focusing on clinical manifestation, diagnosis and treatment.

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Published

2016-01-31

How to Cite

Scalzone M, Ruggiero A, Mastrangelo S, Trombatore G, Ridola V, Maurizi P, Riccardi R (2016) Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: case report and systematic review of literature. J Infect Dev Ctries 10:103–108. doi: 10.3855/jidc.6385

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Issue

Vol. 10 No. 01: January 2016

Section

Case Reports

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