Prevalence of cutaneous warts in patients with systemic lupus erythematosus: a systematic review

  • Luisa Moreira Silva Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil
  • Willer Goncalves Dourado Santos Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil
  • Mittermayer Barretto Santiago Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil
Keywords: Cutaneous warts, Systemic lupus erythematosus, Immunosuppressive drugs, HPV, Human Papillomavirus

Abstract

The aim of this study was to review and evaluate systematically the scientific evidence on the relationship between systemic lupus erythematosus (SLE) and cutaneous warts (CW) caused by human papillomavirus (HPV) infection. With strict inclusion and exclusion criteria, we extensively searched the PUBMED, BVS (Virtual Health Library), and SCOPUS databases for the studies that evaluated the prevalence of CW in patients with SLE. Secondary references were additionally obtained from the selected articles. Only four articles met the research criteria and showed a higher frequency of CW in SLE patients compared to healthy controls. One of them highlighted about rheumatoid factor (RF) in the sera of patients with SLE and found an inverse correlation between the occurrence of warts and RF autoantibody. Moreover, most of the selected articles showed that the presence of CW did not correlate with the use of immunosuppressive drugs. Therefore, these findings suggest that the prevalence of CW in patients with SLE is probably high due to the defects in immune mechanisms, independently of immunosuppressive drugs.

Author Biography

Mittermayer Barretto Santiago, Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil
Adjunct Professor of Rheumatology
Published
2016-09-30
How to Cite
1.
Silva LM, Santos WGD, Santiago MB (2016) Prevalence of cutaneous warts in patients with systemic lupus erythematosus: a systematic review. J Infect Dev Ctries 10:902-906. doi: 10.3855/jidc.7947
Section
Reviews