Risk factors for infection development after transrectal prostate biopsy and the role of resistant bacteria in colonic flora

  • Emine Dilek Eruz Faculty of Medicine, Ankara University, Ankara, Turkey
  • Aysun Yalci Faculty of Medicine, Ankara University, Ankara, Turkey
  • Eriz Ozden Faculty of Medicine, Ankara University, Ankara, Turkey
  • Halide Aslaner Ankara Numune Teaching and Research Hospital, Ankara, Turkey
  • Suna Ogucu-Durgun Izmir Atatürk Teaching and Research Hospital, Izmir, Turkey
  • Deniz Derya Koseoglu-Taymur Bursa Cekirge Public Hospital, Bursa, Turkey
  • Kemal Osman Memikoglu Faculty of Medicine, Ankara University, Ankara, Turkey
  • Hakan Erdem Kasimpasa Military Hospital, Istanbul, Turkey
  • Halil Kurt TOBB University, Ankara, Turkey
Keywords: Prostate biopsy, urinary tract infection, intestinal flora, quinolone resistance, prophylaxis

Abstract

Introduction: In this study, we aimed to identify risk factors for the development of infectious complications after prostate biopsy and to investigate the role of intestinal colonization of bacteria that are resistant to prophylactic antibiotics.

Methodology: A total of 168 patients who had undergone transrectal prostate biopsy (TRPB) under ciprofloxacin and gentamycin prophylaxis were included in the study. Stool cultures and subsequent antibiotic susceptibility testing were performed in all patients before the start of antibiotic prophylaxis.

Results: Of the 168 patients, 17 (10.1%) developed urinary tract infection (UTI), while 6 (3.57%) developed sepsis within seven days after biopsy. Ciprofloxacin-resistant bacterial colonization was detected in 81 (48.2%) of the patients. None of the patients with ciprofloxacin-sensitive bacteria in intestinal flora developed a UTI. The colonization of intestinal ciprofloxacin-resistant bacteria increased UTI risk significantly after TRPB (p < 0.0001). Urolithiasis history, presence of permanent urinary catheterization, hospitalization history for more than 48 hours in the last year, and recent antibiotic usage significantly increased UTI risk after TRPB.

Conclusions: Development of an infection was more frequent in patients with resistant bacterial colonization. We hope to guide more comprehensive studies designed to find a standard prophylactic regimen for TRPB that can be used all over the world.

Author Biographies

Emine Dilek Eruz, Faculty of Medicine, Ankara University, Ankara, Turkey
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine
Aysun Yalci, Faculty of Medicine, Ankara University, Ankara, Turkey

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine

Eriz Ozden, Faculty of Medicine, Ankara University, Ankara, Turkey
Department of Urology, Faculty of Medicine
Halide Aslaner, Ankara Numune Teaching and Research Hospital, Ankara, Turkey
Department of Clinical Microbiology and Infectious Diseases
Suna Ogucu-Durgun, Izmir Atatürk Teaching and Research Hospital, Izmir, Turkey
Department of Clinical Microbiology and Infectious Diseases
Deniz Derya Koseoglu-Taymur, Bursa Cekirge Public Hospital, Bursa, Turkey
Department of Clinical Microbiology and Infectious Diseases
Kemal Osman Memikoglu, Faculty of Medicine, Ankara University, Ankara, Turkey
Department of Infectious Diseases and Clinical Microbiology
Hakan Erdem, Kasimpasa Military Hospital, Istanbul, Turkey
Department of Infectious Diseases and Clinical Microbiology
Halil Kurt, TOBB University, Ankara, Turkey
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine
Published
2017-02-28
How to Cite
1.
Eruz ED, Yalci A, Ozden E, Aslaner H, Ogucu-Durgun S, Koseoglu-Taymur DD, Memikoglu KO, Erdem H, Kurt H (2017) Risk factors for infection development after transrectal prostate biopsy and the role of resistant bacteria in colonic flora. J Infect Dev Ctries 11:188-191. doi: 10.3855/jidc.7067
Section
Brief Original Articles