Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study

Chunhua Liu; Kaiyan Wang; Niyang Lin; Jianling Cai; Binglin Cui; Beiyan Wu

doi:10.3855/jidc.9845

Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study

Authors

Chunhua Liu The First Affiliated Hospital of Shantou University Medical College, Shantou, China
Kaiyan Wang Shantou University Medical College , Shantou, China
Niyang Lin The First Affiliated Hospital of Shantou University Medical College, Shantou, China
Jianling Cai The First Affiliated Hospital of Shantou University Medical College, Shantou, China
Binglin Cui The First Affiliated Hospital of Shantou University Medical College, Shantou, China
Beiyan Wu The First Affiliated Hospital of Shantou University Medical College, Shantou, China

DOI:

https://doi.org/10.3855/jidc.9845

Keywords:

Hand, foot and mouth disease, children, risk factor, enteroviruses, diagnosis

Abstract

Introduction: In clinical perspectives, how to distinguish a small proportion of children at risk of developing neurological complications from a large number of children with mild symptoms still remains a challenge for primary care doctors.

Methodology: From January 2012 to December 2015, 225 cases with severe hand, foot and mouth disease (HFMD) matched with 492 controls were enrolled in the age-matched, case-control study. Continuous variables were examined by univariate analysis using a chi-squared or Fisher’s exact test, and categorical variables were reported by relative risks (odd’s ratio). Multivariate logistic regression was used to analyze the independent risk factors for severe HFMD.

Results: Peak body temperature over 37.5℃，total duration of fever over 3 days, lethargy, enterovirus 71 (EV71) infection were independent risk factors for severe HFMD.

Conclusions: Peak body temperature over 37.5℃，total duration of fever over 3 days, lethargy, EV71 infection were independent risk factors for severe HFMD.

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Published

2018-05-31

How to Cite

Liu C, Wang K, Lin N, Cai J, Cui B, Wu B (2018) Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study. J Infect Dev Ctries 12:359–364. doi: 10.3855/jidc.9845

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Issue

Vol. 12 No. 05: May 2018

Section

Original Articles

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