The antibiotic susceptibility patterns of uropathogens isolated in Qassim, Saudi Arabia‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬

  • Osama Al Wutayd Unaizah College of Medicine, Qassim University, Unaizah, Saudi Arabia
  • Abdullah Al Nafeesah Unaizah College of Medicine, Qassim University, Unaizah, Saudi Arabia
  • Ishag Adam Unaizah College of Medicine, Qassim University, Unaizah, Saudi Arabia
  • Ibrahim Babikir College of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan
Keywords: antimicrobial resistance, multidrug resistance, uropathogens, E. coli, Klebsiella, P. aeruginosa

Abstract

Introduction: Antimicrobial resistance is a global health problem. The present study was carried out to determine the prevalence and antibiotic resistance of uropathogens in the outpatient departments (OPDs) at the clinics of Qassim University, Saudi Arabia.

Methods: A cross-sectional study was conducted from January to December 2016. Nonrepetitive midstream urine samples (1273) were cultured on standard culture media. Identification and susceptibility testing of causative microorganisms was performed using the fully automated VITEK 2 Compact system.

Results: Out of the 1273 nonrepetitive urine samples, 418 (32.8%) exhibited significant growth of UTI-causing microbes, 377 (90.2%) of which were Gram-negative bacilli. The commonly isolated microorganisms were Escherichia coli (157, 37.6%), Klebsiella pneumoniae (70, 16.7%), Proteus mirabilis (17, 4.1%), Pseudomonas aeruginosa (24, 5.8%), Enterobacter cloacae (11, 2.6%), Enterococcus faecalis (12, 2.9%), and Staphylococcus aureus (14, 3.3%). Overall, drug resistance was observed in 91.3% (n=381/418) of the samples, with a majority (80%) exhibiting resistance to at least 2 drugs. Drug resistance was commonly observed against ampicillin (89.9%), oxacillin (75.6%), piperacillin (85.4%), clindamycin (56.1%), amoxicillin/clavulanic acid (74.5%) and trimethoprim/sulfamethoxazole (50.4%).

Conclusion: The uropathogens E. coli, K. pneumoniae and P. aeruginosa and multidrug resistance pose serious therapeutic threats in the setting of this study. A concerted and systematic effort is required to rapidly identify high-risk patients and to reduce the burden of antimicrobial resistance in this region.

Published
2018-11-30
How to Cite
1.
Al Wutayd O, Al Nafeesah A, Adam I, Babikir I (2018) The antibiotic susceptibility patterns of uropathogens isolated in Qassim, Saudi Arabia‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬. J Infect Dev Ctries 12:946-952. doi: 10.3855/jidc.10553
Section
Original Articles